The genome sequence of the virulent Kabete 'O' strain of rinderpest virus: Comparison with the derived vaccine
The genome sequence of the virulent Kabete 'O' strain of rinderpest virus: Comparison with the derived vaccine
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DOI：
10.1099/0022-1317-77-12-3041
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发表时间：
1996-12-01
影响因子：
3.8
通讯作者：
Barrett, T
中科院分区：
文献类型：
--
作者：
Baron, MD;Kamata, Y;Barrett, T
我们已经比较了牛瘟病毒疫苗株和它所来源的强毒株的全基因组序列。两个基因组之间只有87个碱基不同（0.55%）。在N、P、F、H和L蛋白质中发现了可能显著的氨基酸序列差异。在前导区（基因组的3'端）也发现了许多差异，而尾部区域似乎更保守。此外，在这两种情况下发现的基因组长度都是15882，正好是6的倍数，实现了早期基于仙台病毒和麻疹病毒的预测。
We have compared the complete genome sequences of the vaccine strain of rinderpest virus and the virulent strain from which it was derived. Only 87 bases differed between the two genomes (0.55%). Possibly significant differences in amino acid sequence were found in the N, P, F, H and L proteins. A number of differences were also found in the leader region (3' end of the genome), whilst the trailer region appears to be more conserved. In addition, the length of the genome was found in both cases to be 15882, an exact multiple of six, fulfilling predictions made earlier based on work with Sendai and measles viruses.