STAPHYLOCOCCUS-EPIDERMIDIS SEPTICEMIA IN CHILDREN WITH LEUKEMIA AND LYMPHOMA
STAPHYLOCOCCUS-EPIDERMIDIS SEPTICEMIA IN CHILDREN WITH LEUKEMIA AND LYMPHOMA
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DOI：
10.1001/archpedi.1984.02140460007005
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发表时间：
1984-01-01
影响因子：
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通讯作者：
ARMSTRONG, D
中科院分区：
文献类型：
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作者：
FRIEDMAN, LE;BROWN, AE;ARMSTRONG, D
表皮葡萄球菌正在成为免疫功能低下患者发病和死亡的一个原因。从 1980 年 1 月到 1982 年 6 月，纽约纪念斯隆-凯特琳癌症中心的 92 名患有白血病和淋巴瘤的儿童发生了 150 次败血症。表皮葡萄球菌是第四大最常见的分离微生物，占所有败血症发作的 12.7%。 53 个分离株中只有 9 个对甲氧西林敏感；所有患者均对万古霉素敏感。表皮葡萄球菌败血症与免疫抑制化疗相关（94.7%）；广谱抗生素（79.0%）；导管和引流管（73.7%）；中性粒细胞减少症（63.2%）；皮肤或软组织感染（42.1%）；既往败血症（42.1%）；并发多种微生物败血症（21.1%）；住院时间延长（平均 39 天）。 19名患者中，2人死亡。当已知有败血症临床证据的患者中分离到该微生物时，需要提高对表皮葡萄球菌在患有血液系统恶性肿瘤的儿童中的致病潜力的认识，并立即改变治疗为有效的抗菌药物（在大多数情况下为盐酸万古霉素）。
S. epidermidis is emerging as a cause of morbidity and mortality in immunocompromised patients. From Jan. 1980 through June 1982, there were 150 episodes of septicemia in 92 children with leukemia and lymphoma at Memorial Sloan-Kettering Cancer Center, New York [USA]. S. epidermidis was the fourth most common organism isolated, responsible for 12.7% of all septicemic episodes. Only 9 of 53 isolates were sensitive to methicillin; all were sensitive to vancomycin. S. epidermidis septicemia was associated with immunosuppressive chemotherapy (94.7%); broad-spectrum antibiotics (79.0%); catheters and drains (73.7%); neutropenia (63.2%); skin or soft-tissue infections (42.1%); prior septicemia (42.1%); concurrent polymicrobial septicemia (21.1%); and prolonged hospitalization (mean, 39 days). Of 19 patients, 2 died. Increased awareness of the pathogenic potential of S. epidermidis in children with hematologic malignancies and prompt alteration of therapy to an effective antimicrobial agent, in most cases vancomycin hydrochloride, is required when the organism is isolated in patients known to be at risk with clinical evidence of septicemia.