Many paths to preserve the body clock.
Many paths to preserve the body clock.
复制标题
保持生物钟的途径有很多。
DOI：
10.1126/science.aav9706
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Green,CarlaB
中科院分区：
文献类型：
--
作者：
Green,CarlaB
行为学、生理学和生物化学的日常波动是由内源性计时机制——生物钟驱动的。哺乳动物的生物钟最初被认为是神经系统的特性，该生物钟的解剖位置被确定为下丘脑的视交叉上核（SCN）。构成这一结构的神经元是高度相互连接（耦合）的，并表现出强大而协调的活动节奏，节律性的丧失会导致日常活动等行为节奏的丧失。在本刊第187页，Brancaccioet al.(1)揭示，通过基因扰动使小鼠的scn变得“无时钟”，可以通过挽救星形胶质细胞（一种胶质细胞）中的时钟来恢复节律性。有节律的星形胶质细胞足以产生一个能够控制行为节律的功能性生物钟，这一想法令人惊讶，并表明SCN可以通过多种机制产生节律。
Robust daily oscillations in behavior, physiology, and biochemistry are driven by endogenous timekeeping machinery called the circadian clocks. Circadian clocks in mammals were originally considered properties of the nervous system, and the anatomical locus of this clock was determined to be the suprachiasmatic nucleus (SCN) in the hypothalamus. The neurons that make up this structure are highly interconnected (coupled) and exhibit robust and coordinated rhythms of activity, and loss of rhythmicity results in loss of behavioral rhythms such as daily activity. On page 187 of this issue, Brancaccioet al.(1) reveal that SCNs that have been rendered “clockless” through genetic perturbation in mice can be restored to rhythmicity by rescuing the clocks in only the astrocytes, a type of glial cell. The idea that rhythmic astrocytes are sufficient to generate a functional circadian clock that can control behavioral rhythms is surprising and suggests that the SCN can produce rhythms by means of more than one mechanism.