Fibrous PCL/PLLA Scaffolds Obtained by Rotary Jet Spinning and Electrospinning
Fibrous PCL/PLLA Scaffolds Obtained by Rotary Jet Spinning and Electrospinning
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通过旋转喷射纺丝和静电纺丝获得纤维状 PCL/PLLA 支架
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
C. Zavaglia
中科院分区：
文献类型：
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作者：
Talita A. Vida;A. Motta;A. R. Santos;G. C. Cardoso;C. Brito;C. Zavaglia
旋转喷射纺丝和静电纺丝是制备纤维支架的两种技术。RJS是一种简单的方法，它利用高速旋转的喷嘴制造三维纤维，产生拉伸直至凝固的聚合物射流，并且不需要高电压。相反，静电纺丝技术需要外部电场的存在才能从聚合物喷射溶液中产生纤维。本文研究了两种不同的生物相容性聚合物：聚l -乳酸（PLLA）和聚ε-己内酯（PCL）。采用扫描电子显微镜、热重分析、差示扫描量热仪和傅里叶变换红外光谱对样品进行了表征。形态学观察表明这两种方法都能获得纳米纤维。热分析数据表明了不同共混物的不混溶性和溶剂总蒸发。体外细胞相容性试验表明，RJS和静电纺丝样品均表现出良好的细胞相容性。综上所述，两种技术制备的纤维均无细胞毒性，具有良好的生物相容性，可作为细胞生长支架。
Rotary jet spinning (RJS) and electrospinning are techniques to obtain fibrous scaffolds. RJS is a simple method, which fabricates three-dimensional fibers by exploiting a high-speed rotating nozzle, creating a polymer jet which stretches until solidification, and does not require high voltage. In opposite, electrospinning technique needs the presence of an external electric field to create fiber from the polymeric jet solution. This article investigates both processes using two different biocompatible polymers: Poly(L-lactic acid) (PLLA) and Poly(ε-caprolactone) (PCL). Samples were characterized by scanning electron microscopy, thermogravimetric analysis, differential scanning calorimeter, and Fourier-transform infrared spectroscopy. Morphological observations showed the efficiency of both techniques in obtaining nanofibers. Thermal analyses of data indicate immiscible property of different blends and the total solvent evaporation. In vitro cytocompatibility test showed that RJS and electrospinning samples exhibited good cytocompatibility. Based on these results, it may be concluded that the fibers obtained with both technologies are non-cytotoxicity and with good biocompatibility, and might be suitable for applications as scaffold for cell growth.