Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints.
Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints.
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癌症免疫治疗：关注免疫检查点的调节。
DOI：
10.3390/ijms19051389
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发表时间：
2018-05-07
影响因子：
5.6
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Shi T;Ma Y;Yu L;Jiang J;Shen S;Hou Y;Wang T
近年来，与传统的癌症治疗（包括手术、化疗和放疗）相比，癌症免疫治疗的作用变得越来越重要。值得注意的是，免疫检查点阻断（如PD-1和CTLA-4）的临床成功代表了癌症免疫治疗开发中的里程碑事件。因此，进一步探索免疫检查点如何在肿瘤微环境中调节将为检查点阻断治疗提供关键见解。本文就免疫细胞、溶瘤病毒、表观遗传学和肠道菌群对免疫检查点的调控以及共表达检查点的相互调控作一综述。最后，基于不同的检查点调节，对未来的个性化癌症免疫治疗进行了预测。
In recent years, the role of cancer immunotherapy has become increasingly important compared to traditional cancer treatments, including surgery, chemotherapy and radiotherapy. Of note, the clinical successes of immune checkpoint blockade, such as PD-1 and CTLA-4, represent a landmark event in cancer immunotherapy development. Therefore, further exploration of how immune checkpoints are regulated in the tumor microenvironment will provide key insights into checkpoint blockade therapy. In this review, we discuss in details about the regulation of immune checkpoints mediated by immune cells, oncolytic viruses, epigenetics, and gut microbiota and mutual regulation by co-expressed checkpoints. Finally, predictions are made for future personalized cancer immunotherapy based on different checkpoint modulations.
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DOI：
10.1002/art.40399
发表时间：
2018-04
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Fleury M;Belkina AC;Proctor EA;Zammitti C;Simms RW;Lauffenburger DA;Snyder-Cappione JE;Lafyatis R;Dooms H
通讯作者：
Dooms H
影响因子：
82.9
作者：
Gao J;Ward JF;Pettaway CA;Shi LZ;Subudhi SK;Vence LM;Zhao H;Chen J;Chen H;Efstathiou E;Troncoso P;Allison JP;Logothetis CJ;Wistuba II;Sepulveda MA;Sun J;Wargo J;Blando J;Sharma P
通讯作者：
Sharma P
影响因子：
11.2
作者：
Bartee MY;Dunlap KM;Bartee E
通讯作者：
Bartee E
影响因子：
3.7
作者：
Foks, Amanda C.;Ran, Ingrid A.;van Puijvelde, Gijs H. M.
通讯作者：
van Puijvelde, Gijs H. M.
DOI：
10.1016/j.jtho.2017.04.017
发表时间：
2017-08
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Akbay EA;Koyama S;Liu Y;Dries R;Bufe LE;Silkes M;Alam MM;Magee DM;Jones R;Jinushi M;Kulkarni M;Carretero J;Wang X;Warner-Hatten T;Cavanaugh JD;Osa A;Kumanogoh A;Freeman GJ;Awad MM;Christiani DC;Bueno R;Hammerman PS;Dranoff G;Wong KK
通讯作者：
Wong KK