Impulsiveness as the intermediate link between the dopamine receptor D2 gene and alcohol dependence
Impulsiveness as the intermediate link between the dopamine receptor D2 gene and alcohol dependence
复制标题
冲动是多巴胺受体 D2 基因与酒精依赖之间的中间环节
DOI：
10.1097/01.ypg.0000066963.66429.00
复制
发表时间：
2003
影响因子：
0.9
通讯作者：
P. Gorwood
中科院分区：
文献类型：
--
作者：
F. Limosin;J. Loze;C. Dubertret;L. Gouya;J. Adès;F. Rouillon;P. Gorwood
目的强化和奖励过程被认为是酒精依赖风险与多巴胺受体D2（DRD 2）基因编码之间的中间环节。这一假设仍然值得商榷，而人格特征，如冲动，成瘾性障碍的核心维度，也应该考虑在内。例如，最近在大鼠中的证据表明，DRD 2拮抗剂可能会增加冲动性，降低延迟奖励的价值。方法考虑到在临床实践和流行病学研究中观察到的乙醇的促冲动作用，我们根据DRD 2基因的TaqI A多态性分析了92例酒精依赖法国患者（57例男性和35例女性）的Barratt冲动评分。结果A2/A2和A1/A2基因型与总体冲动性显著相关（P = 0.02），而A1/A1基因型与总体冲动性显著相关（P =0.03）。结论我们认为，奖赏相关的冲动可能是酒精依赖的一个危险因素，这种核心气质可能部分由DRD 2基因介导。
Objectives Reinforcement and reward processes have been proposed as being an intermediate link between the risk for alcohol dependence and the gene coding for the dopamine receptor D2 (DRD2). This hypothesis remains open to speculation, and personality traits such as impulsiveness, a core dimension in addictive disorders, should also be taken into account. For instance, recent evidence in rats showed that DRD2 antagonists might increase impulsivity in decreasing the value of delayed rewards. Methods Considering the pro‐impulsiveness role of ethanol observed in clinical practice and epidemiological studies, we analysed the Barratt impulsiveness scores in a sample of 92 alcohol‐dependent French patients (57 men and 35 women), according to the TaqI A polymorphism of the DRD2 gene. Results A2/A2 and A1/A2 genotypes were significantly associated with a higher global impulsiveness than A1/A1 genotype (P = 0.02 and P =0.03, respectively). Conclusions We propose that reward‐related impulsiveness may constitute a risk factor for alcohol dependence, and that this core temperament could be partly mediated by the DRD2 gene.
影响因子：
4.4
作者：
HAUGE, XY;GRANDY, DK;LITT, M
通讯作者：
LITT, M
DOI：
10.15288/jsa.2000.61.5
发表时间：
2000-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Li, TK
通讯作者：
Li, TK