Rapid forgetting of social learning in the Ts65Dn mouse model of Down syndrome: New evidence for hippocampal dysfunction.
Rapid forgetting of social learning in the Ts65Dn mouse model of Down syndrome: New evidence for hippocampal dysfunction.
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DOI：
10.1037/bne0000227
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发表时间：
2018-03
影响因子：
1.9
通讯作者：
Strupp BJ
中科院分区：
文献类型：
--
作者：
Powers BE;Santiago NA;Strupp BJ
唐氏综合征的Ts 65 Dn小鼠模型概括了表征人类疾病的功能障碍的标志性领域，包括在旨在挖掘依赖于大脑的学习和记忆的任务中的表现受损。不幸的是，最常用于此目的的水迷宫任务中的表现可能受到Ts 65 Dn小鼠的行为和/或生理异常特征的影响（例如，趋触性、对低温的敏感性、应激反应性），这使得对受损表现的解释复杂化。本研究使用食物偏好的社会传递（STFP）范式评估Ts 65 Dn小鼠的海马功能，该范式不需要水逃逸或厌恶强化，从而避免了这些解释性混淆。我们测试了Ts 65 Dn小鼠和二体对照使用1和7天的保留时间间隔。Ts 65 Dn小鼠在1天的保持间隔后表现出正常的学习和记忆，但快速忘记社交获得的信息，这通过7天的保持间隔后的表现受损来证明。STFP范例可以是使用Ts 65 Dn小鼠模型进行研究的有价值的工具，以评估可能改善唐氏综合征中海马功能障碍和衰老相关的认知下降的潜在疗法。
The Ts65Dn mouse model of Down syndrome recapitulates the hallmark areas of dysfunction that characterize the human disorder, including impaired performance in tasks designed to tap hippocampus-dependent learning and memory. Unfortunately, performance in the water maze tasks most commonly used for this purpose can be affected by behavioral and/or physiological abnormalities characteristic of Ts65Dn mice (e.g., thigmotaxis, susceptibility to hypothermia, stress reactivity), which complicates interpretation of impaired performance. The current study assessed hippocampal function in Ts65Dn mice using the social transmission of food preference (STFP) paradigm, which does not entail water escape or aversive reinforcement, and thus avoids these interpretive confounds. We tested Ts65Dn mice and disomic controls on this task using 1- and 7-day retention intervals. The Ts65Dn mice exhibited normal learning and memory following the 1-day retention interval, but rapid forgetting of the socially acquired information, evidenced by impaired performance following the 7-day retention interval. The STFP paradigm can be a valuable tool for studies using the Ts65Dn mouse model to evaluate potential therapies that may ameliorate hippocampal dysfunction and aging-related cognitive decline in Down syndrome.
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影响因子：
3.3
作者：
Powers BE;Kelley CM;Velazquez R;Ash JA;Strawderman MS;Alldred MJ;Ginsberg SD;Mufson EJ;Strupp BJ
通讯作者：
Strupp BJ
影响因子：
5.3
作者：
Bianchi, Patrizia;Ciani, Elisabetta;Bartesaghi, Renata
通讯作者：
Bartesaghi, Renata
DOI：
10.1073/pnas.93.23.13333
发表时间：
1996-11-12
影响因子：
11.1
作者：
Holtzman, DM;Santucci, D;Mobley, WC
通讯作者：
Mobley, WC
影响因子：
5
作者：
Fuchs, Claudia;Ciani, Elisabetta;Bartesaghi, Renata
通讯作者：
Bartesaghi, Renata
影响因子：
1.9
作者：
Driscoll, LL;Carroll, JC;Strupp, BJ
通讯作者：
Strupp, BJ