Regulation of the polymeric immunoglobulin receptor by water intake and vasopressin in the rat kidney.
Regulation of the polymeric immunoglobulin receptor by water intake and vasopressin in the rat kidney.
复制标题
大鼠肾脏中饮水和加压素对聚合免疫球蛋白受体的调节。
DOI：
10.1152/ajprenal.1998.274.5.f966
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Goldblum,RM
中科院分区：
文献类型：
--
作者：
Rice,JC;Spence,JS;Megyesi,J;Safirstein,RL;Goldblum,RM
The polymeric immunoglobulin receptor (pIgR) transports polymeric immunoglobulins (IgA) from the basolateral to the apical surface of epithelial cells. At the apical surface, its amino-terminal domain, termed secretory component (SC), is proteolytically cleaved and released either unbound (free SC) or bound to IgA. We examined the effects of changes in water balance and vasopressin on the production and secretion of the pIgR in the rat kidney in vivo. Water deprivation induced a 2.7-fold increase in the pIgR mRNA and a 2.2-fold increase in intracellular pIgR protein compared with water-loaded animals. Physiological doses of desmopressin reproduced the effects of water deprivation on mRNA and intracellular protein levels, suggesting that pIgR expression may be regulated by a vasopressin-coupled mechanism. Secretion of free SC and secretory IgA in the urine, however, correlated directly with water intake and urine flow. These results suggest that hydration status and vasopressin may affect the mucosal immunity of the kidney by regulating at different steps the epithelial cell production and secretion of the polymeric immunoglobulin transporter/secretory component.
