A comparative study of development during primary palate formation in A/WySn, C57BL/6, and their F1 crosses.
A comparative study of development during primary palate formation in A/WySn, C57BL/6, and their F1 crosses.
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A/WySn、C57BL/6 及其 F1 杂交中初级上颚形成过程中发育的比较研究。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
V. Diewert
中科院分区：
文献类型：
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作者：
D. Ciriani;V. Diewert
初步研究比较A/WySn（25%唇裂）和C57 BL/6（0%唇裂）小鼠面部生长的形态学差异，检查这些品系及其相互F1杂种的生长和发育。在D 10/8、D 10/20、D 11/8和D 11/20观察这四个种群的窝仔，并对顶臀长度（CRL）、体节数和面部发育阶段进行评分。对数据的分析表明，在任何给定的胎龄，存在一个层次结构，其中A/WySn是最小的（基于CRL），体节最少，面部发育最差。其次是A/WySn-C57 BL/6（AC）杂交，C57 BL/6和C57 BL/6-A/WySn（CA）杂交，以增加生长和发育的顺序。AC和CA之间的显著差异表明，在A/WySn中存在母体效应，阻碍其后代的生长和发育。当4个群体在相似的面部阶段进行比较时，A/WySn和C57 BL/6之间的CRL或体节数没有显著差异。然而，杂交种群往往有显着更少的体节，并显着大于父母的人口在面部发育的可比阶段。这表明，虽然体细胞的生长和发育协调与面部发育的唇裂敏感和耐药株，该协会可以影响杂种优势。因此，母亲的影响似乎不会产生唇裂通过选择性阻滞面部发育的纯种A/WySn。尽管如此，这些影响仍然可能加强唇裂的表达。
Preliminary to a study comparing the morphological differences in facial growth of A/WySn (25% cleft lip) and C57BL/6 (0% cleft lip) mice, the growth and development of these strains and their reciprocal F1 hybrids was examined. Litters of these four populations were observed at D 10/8, D 10/20, D 11/8, and D 11/20 and scored for crown-rump length (CRL), somite number, and stage of facial development. Analysis of the data showed that, at any given gestational age, a hierarchy exists in which A/WySn is the smallest (based on CRL), has the fewest somites, and has the least-developed face. It is followed by the A/WySn-C57BL/6 (AC) cross, C57BL/6, and the C57BL/6-A/WySn (CA) cross, in order of increasing growth and development. The significant differences occurring between AC and CA indicate that maternal effects exist in A/WySn that retard the growth and development of its progeny. When the four populations were compared at similar facial stages, there was no significant difference between A/WySn and C57BL/6 in CRL or somite number. However, the hybrid populations tended to have significantly fewer somites and to be significantly larger than the parental populations at comparable stages of facial development. This suggests that, although somatic growth and development are coordinated with facial development in both cleft lip-susceptible and resistant strains, the association can be influenced by hybrid vigor. Thus, maternal effects do not appear to produce cleft lip through selective retardation of facial development in the purebred A/WySn. Nonetheless, these effects may still potentiate the expression of cleft lip.