Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
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DOI：
10.1038/nm1752
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发表时间：
2008-05-01
期刊：
影响因子：
82.9
通讯作者：
Isacson, Ole
中科院分区：
文献类型：
--
作者：
Mendez, Ivar;Vinuela, Angel;Isacson, Ole
对5名帕金森氏病患者在移植胎儿中脑细胞悬浮液9-14年后的尸检分析显示，包括多巴胺和5-羟色胺神经元在内的移植物存活，没有病理变化。这些发现对于理解中脑多巴胺神经元变性的发病机制和未来细胞替代疗法的使用具有重要意义。
Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.