Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo
Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo
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DOI：
10.4049/jimmunol.179.10.7021
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发表时间：
2007-11-15
影响因子：
4.4
通讯作者：
Van Dyke, Thomas E.
中科院分区：
文献类型：
--
作者：
Hasturk, Hatice;Kantarci, Alpdogan;Van Dyke, Thomas E.
消退素E1（RvE1）是一种源自ω - 3二十碳五烯酸的强效炎症消退介质，它在局部发挥作用，阻止白细胞募集并促进炎症消退。RvE1在体外和体内均显示出强大的反调节和组织保护作用。牙周病是一种由细菌引发的局部炎症性疾病，其特征是中性粒细胞介导的组织损伤，随后发展为慢性免疫损伤。在这项研究中，我们报告了在兔子身上使用RvE1作为单一疗法治疗已形成的牙周炎的情况，并与结构相关的脂质前列腺素E₂（PGE₂）和白三烯B - 4进行了比较。PGE₂和白三烯B - 4各自都加剧了牙周炎的发展并使疾病的严重程度恶化。将促进炎症消退作为使用RvE1的治疗靶点，使得局部病变完全恢复，并降低了全身性炎症标志物C - 反应蛋白和白细胞介素 - 1β。本报告首次表明，一种天然存在的内源性脂质介质促进炎症消退可导致病理缺失组织（包括骨骼）的完全再生。
Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapentaenoic acid that acts locally to stop leukocyte recruitment and promote resolution. RvE1 displays potent counter-regulatory and tissue-protective actions in vitro and in vivo. Periodontal disease is a local inflammatory disease initiated by bacteria characterized by neutrophilmediated tissue injury followed by development of a chronic immune lesion. In this study, we report the treatment of established periodontitis using RvE1 as a monotherapy in rabbits compared with structurally related lipids PGE(2) and leukotriene B-4 center dot PGE(2) and leukotriene B-4 each enhanced development of periodontitis and worsened the severity of disease. Promotion of resolution of inflammation as a therapeutic target with RvE1 resulted in complete restoration of the local lesion, and reduction in the systemic inflammatory markers C-reactive protein and IL-1 beta. This report is the first to show that resolution of inflammation by a naturally occurring endogenous lipid mediator results in complete regeneration of pathologically lost tissues, including bone.