Impairment of an Electroconvulsive Stimulus on Reconsolidation of Memories Established by Conditioning
Impairment of an Electroconvulsive Stimulus on Reconsolidation of Memories Established by Conditioning
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DOI：
10.4077/cjp.2013.baa048
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发表时间：
2013-02-28
影响因子：
1.8
通讯作者：
Yu, Lung
中科院分区：
文献类型：
--
作者：
Lu, Tsun-Jung;Lu, Ru-Band;Yu, Lung
推断的记忆巩固和再巩固阶段对类似的遗忘和记忆增强治疗很敏感。众所周知，电惊厥刺激会损害记忆巩固。因此，我们假设电惊厥刺激可能会破坏条件反射记忆的再巩固。在回忆起可卡因诱导的条件性位置偏好（CPP）后，立即在小鼠耳廓之间传递 200 毫秒的电惊厥刺激（500 V，25 mA），会损害该记忆的重新巩固和随后的表达。相比之下，当省略回忆程序时，电惊厥刺激（500 V，25 mA，持续 200 ms）不会影响随后的可卡因诱导的 CPP 表现。 CPP 测试后立即全身注射戊巴比妥并不影响随后的可卡因诱导的 CPP。有趣的是，当小鼠在整个 ECS 方案中用戊巴比妥麻醉时，在回忆起可卡因诱导的 CPP 后立即给予的几种电惊厥刺激方案并不影响随后的 CPP 表现。最后，在被动回避（PA）和食物诱导的 CPP 重新激活后立即提供 ECS（500 V，25 mA，持续 200 ms）会损害这些记忆在重新测试中的后续表现。综上所述，我们得出的结论是，短暂的电惊厥刺激会破坏通过条件反射建立的各种形式的记忆的重新巩固。
The deduced memory consolidation and reconsolidation phases are sensitive to similar amnesic and memory-enhancing treatment. Electroconvulsive stimulus has been well known to impair memory consolidation. Therefore, we hypothesized that electroconvulsive stimulus might disrupt reconsolidation for conditioning-established memories. Delivery of a 200-msec electroconvulsive stimulus (500 V, 25 mA) between mouse pinnas immediately after recall of the cocaine-induced conditioned place preference (CPP) impaired the reconsolidation and subsequent expression of this memory. In contrast, the electroconvulsive stimulus (500 V, 25 mA, lasting for 200 ms) did not affect subsequent cocaine-induced CPP performance when the recall procedure was omitted. Systemic pentobarbital injection immediately after the CPP test did not affect subsequent cocaine-induced CPP. Interestingly, several regimens of electroconvulsive stimulus given immediately after the recall of cocaine-induced CPP did not affect subsequent CPP performance when mice were anesthetized by pentobarbital throughout the ECS regimens. Finally, delivery of the ECS (500 V, 25 mA, lasting for 200 ms) immediately after the reactivation of passive avoidance (PA) and food-induced CPP impaired subsequent performance of these memories in the retest. Taken together, we conclude that a short-lasting electroconvulsive stimulus can deteriorate the reconsolidation of various forms of memory established by conditioning.