The regulator of calcineurin 1 (RCAN1) inhibits nuclear factor kappaB signaling pathway and suppresses human malignant glioma cells growth.
The regulator of calcineurin 1 (RCAN1) inhibits nuclear factor kappaB signaling pathway and suppresses human malignant glioma cells growth.
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钙调磷酸酶 1 (RCAN1) 调节因子抑制核因子 kappaB 信号通路并抑制人恶性胶质瘤细胞生长
DOI：
10.18632/oncotarget.14479
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发表时间：
2017-02-14
期刊：
影响因子：
--
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Chen X;Hu Y;Wang S;Sun X
核因子-κB（NF-κB）在细胞存活中起着至关重要的作用，尽管其潜在机制尚不清楚，但抑制NF-κB已被证明是治疗多种癌症的有效途径。此前，我们发现钙调神经磷酸酶调节因子1（RCAN1）是淋巴瘤中NF-κB信号通路的内源性抑制剂。在本研究中，我们有确凿的数据表明，RCAN1可抑制NF-κB蛋白的核转位，进而影响胶质瘤细胞中NF-κB信号通路的活性。RCAN1的过表达显著降低了胶质瘤细胞的活力。我们进一步发现，RCAN1抑制胶质瘤细胞生长与促凋亡作用密切相关，而非通过阻滞细胞周期抑制细胞增殖。我们的研究表明，RCAN1通过抑制NF-κB信号通路，为胶质瘤治疗提供了一种新的方法。
Nuclear factor-kappaB (NF-κB) has a vital role in cell survival and inhibition of NF-κB had proven to be an efficient therapeutic pathway for various cancers though little is known about the underlying mechanism. Previously we identified regulator of calcineurin 1 (RCAN1) as an endogenous inhibitor of NF-κB signaling pathway in lymphoma. In the present study, we have solid data to show that RCAN1 can inhibit the nuclear translocation of NF-κB protein then affect the activity of NF-κB signaling pathway in glioma cells. Overexpression of RCAN1 markedly reduced glioma cells viability. We further found that the suppressing glioma cell growth was closely related to the pro-apoptosis effect, not by inhibiting proliferation by the arrest of cell cycle. Our study implicated a novel therapeutic approach for glioma by RCAN1 through inhibition of NF-κB signaling.