Urogenital Infections as a Risk Factor for Preterm Labor: A Hospital-Based Case-Control Study
Urogenital Infections as a Risk Factor for Preterm Labor: A Hospital-Based Case-Control Study
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DOI：
10.1007/s13224-014-0523-6
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发表时间：
2014-07-01
影响因子：
0.7
通讯作者：
Vandana, Berry
中科院分区：
文献类型：
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作者：
Indu, Verma;Kumkum, Avasthi;Vandana, Berry
目的早产是新生儿发病和死亡的主要原因。上行性下生殖道感染可导致早产和不良妊娠结局。本前瞻性病例对照研究进行早产和泌尿生殖道infections.Methods之间的关联，共104名妇女进行了观察泌尿生殖道感染和早产的关联。病例组I包括52名在妊娠26周后和37周前发生早产的妇女，有或无胎膜破裂。对照组II包括52名妇女在完成或超过37周的妊娠，没有早产的历史，匹配的情况下组的年龄和胎次。中段尿送去进行细胞学和培养敏感性。在首次阴道检查前，使用库斯科/西姆斯窥镜在直视下用两个无菌拭子从阴道后穹窿取样，并通过标准方法研究革兰氏染色特征和培养敏感性。记录培养分离的微生物，并根据敏感性给予抗生素。结果病例组I中有19例女性发生泌尿生殖道感染（36.54%），而对照组中有9名妇女（17.3%），差异有统计学意义结论在泌尿生殖道感染尚不明显时及时发现并治疗，可降低早产率，改善围生儿结局。
Purpose Preterm labor is a leading cause of neonatal morbidity and mortality. Ascending lower genital tract infection leads to preterm labor and adverse pregnancy outcomes. This prospective case-control study was performed to see the association between preterm labor and urogenital infections.Methods A total of 104 women were observed for urogenital infections and their association with preterm labor. Case Group I included 52 women with preterm labor after 26 weeks and before 37 completed weeks of gestation with or without rupture of membranes. Control Group II included 52 women at completed or more than 37 weeks of gestation with no history of preterm labor, matched to the case group with respect to age and parity. Midstream urine was sent for cytology and culture sensitivity. Samples from posterior fornix of vagina were taken with two sterilized swabs under direct vision using Cusco/ Sims speculum before first vaginal examination and were studied for gram stain characteristics and culture sensitivity by standard methods. Microorganisms isolated on culture were noted, and antibiotics were given according to sensitivity. Data collected were analyzed according to the groups by chi(2) test for categorical variables.Results In our study, urogenital infection was seen in 19 women in Case Group I (36.54 %) compared with 9 women in Control Group (17.3 %), and the difference was statistically significant (p 0.027).Conclusion Recognizing and treating the women having urogenital infections at a stage, when it has not become clinically evident, will decrease the percentage of women going into preterm labor and will improve the perinatal outcome.