A follow-up study of environmental and biologic determinants of fertility among 430 Danish first-pregnancy planners: Design and methods
A follow-up study of environmental and biologic determinants of fertility among 430 Danish first-pregnancy planners: Design and methods
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DOI：
10.1016/s0890-6238(97)00096-8
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发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Olsen, J
中科院分区：
文献类型：
--
作者：
Bonde, JPE;Hjollund, NHI;Olsen, J
本文介绍了首次怀孕计划者生育能力（定义为一个月经周期内受孕的可能性）随访研究的设计和方法。我们通过邮寄方式在四个工会的52，255名成员中招募了430对夫妇。没有早期生育经验的夫妇在停止避孕时被招募，并在六个完整的月经周期或直到怀孕被确认。数据包括性交和月经出血的每日记录，收集血液、精液和尿液样本以评估内分泌特征、精液质量、隐性胚胎丢失和职业暴露。获得了约1661个月经周期的信息（预期的94%）。随访6个月，临床妊娠率为65%，平均妊娠率为16%（95% CI 14-18%），早期胚胎丢失率为17%（95% CI 12-22%）。这项研究表明，生育力的前瞻性研究的可行性，建立的研究基地，可以提供有用的信息，环境风险的生育力低下。(C)1998年爱思唯尔科学公司
This paper presents design and methods of a follow-up study of fecundability (defined as the probability of conception during one menstrual cycle) in first-pregnancy planners, We recruited 430 couples by postal letter among 52,255 members of four trade unions. Couples without earlier reproductive experience were enrolled when they discontinued contraception and were followed in six complete menstrual cycles or until a pregnancy was recognized. Data included daily recordings of coitus and menstrual bleeding, Blood, semen, and urine specimens were collected to assess endocrine profile, semen quality, occult embryonal loss, and occupational exposures, Information was obtained about 1661 menstrual cycles (94% of expected). The proportion of couples obtaining a clinical pregnancy during 6 months of follow-up was 65%, and the average probability to obtain a pregnancy across all cycles was 16% (95% CI 14-18%), Among all conceptions the proportion of early embryonal loss was 17% (95% CT 12-22%). This study demonstrates the feasibility of a prospective study of fertility and that the established study base can provide useful information on environmental risk to subfertility. (C) 1998 Elsevier Science Inc.