In vivo measurement of regional brain metabolic response to hyperventilation using magnetic resonance: Proton echo planar spectroscopic imaging (PEPSI)
In vivo measurement of regional brain metabolic response to hyperventilation using magnetic resonance: Proton echo planar spectroscopic imaging (PEPSI)
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DOI：
10.1002/mrm.1910370609
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发表时间：
1997-06-01
影响因子：
3.3
通讯作者：
Hayes, C
中科院分区：
文献类型：
--
作者：
Posse, S;Dager, SR;Hayes, C
一种新的快速光谱成像技术，具有更高的灵敏度和脂质抑制，被称为质子回波平面光谱成像（PEPSI），已被开发用于测量2维分布的脑乳酸增加在过度通气的常规临床扫描仪配备了一个头表面线圈相控阵。在正常碳酸血症的8.5分钟基线期和二氧化碳测定控制的过度通气（潮气末PCO 2为20 mmHg）的10分钟期的最后8.5分钟期间，从连合线下方约20 mm的轴向切片获得5名健康受试者的PEPSI图像（标称体素大小：1.125 cm（3））。在换气过度期间，左、右半球的岛叶皮质、颞叶皮质和枕叶区域的乳酸/N-乙酰天冬氨酸信号较基线显著增加，但基底神经节中无此现象。区域或半球的右至left. The研究扩展了以前的工作，使用单体素磁共振波谱动态研究过度换气对大脑代谢的影响。
A new rapid spectroscopic imaging technique with improved sensitivity and lipid suppression, referred to as Proton Echo Planar Spectroscopic Imaging (PEPSI), has been developed to measure the 2-dimensional distribution of brain lactate increases during hyperventilation on a conventional clincal scanner equipped with a head surface coil phased array. PEPSI images (nominal voxel size: 1.125 cm(3)) in five healthy subjects from an axial section approximately 20 mm inferior to the intercommissural line were obtained during an 8.5-min baseline period of normocapnia and during the final 8.5 min of a 10-min period of capnometry-controlled hyperventilation (end-tidal PCO2 of 20 mmHg). The lactate/N-acetyl aspartate signal increased significantly from baseline during hyperventilation for the insular cortex, temporal cortex, and occipital regions of both the right and left hemispheres, but not in the basal ganglia. Regional or hemispheric right-to-left differences were not found. The study extends previous work using single-voxel MR spectroscopy to dynamically study hyperventilation effects on brain metabolism.