ANXIOGENIC PROPERTIES OF YOHIMBINE .2. INFLUENCE OF EXPERIMENTAL SET AND SETTING
ANXIOGENIC PROPERTIES OF YOHIMBINE .2. INFLUENCE OF EXPERIMENTAL SET AND SETTING
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DOI：
10.1007/bf02191959
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发表时间：
1992-07-01
影响因子：
4.7
通讯作者：
BREIER, A
中科院分区：
文献类型：
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作者：
ALBUS, M;ZAHN, TP;BREIER, A
为了研究应激沿着心理应激的药理学诱导及其可能的相互作用，在双盲交叉设计中，对8名安慰剂治疗的惊恐患者、7名阿普唑仑治疗的惊恐患者和12名对照者口服20 mg育亨宾和安慰剂。两个结构化的情况下，可以被认为是“中性”的压力，包括：心算任务和连续的性能任务。心算引起的恐慌，焦虑，紧张，心率和皮肤电活动的评级大幅增加，而连续的性能任务引起的增加专门在皮肤电导反应。患者对这些任务的反应低于对照组的主观评分和皮肤电活动。育亨宾没有增强患者对任务的反应。在对照组中，服用育亨宾后，心算任务中的心率增加，而休息时心率没有增加。与其他育亨宾激发研究相反，未观察到惊恐发作。据推测，实验设计与教学设置，减少预期因素和列入结构化和有时间限制的任务，在一个挑战的范例是能够减少育亨宾的焦虑作用。
To study the pharmacological induction of stress along with psychological stress and their possible interaction, 20 mg yohimbine and placebo orally were administered to 8 panic patients on placebo treatment, 7 panic patients on alprazolam treatment and 12 controls in a double-blind crossover design. Two structured situations which can be considered as 'neutral' stressors were included: a mental arithmetic task and a continuous performance task. Mental arithmetic induced robust increases in ratings of panicky, anxiety, nervousness, heart rate and electrodermal activity, while the continuous performance task induced increases exclusively in skin conductance reaction. Patients responded to these tasks less than controls with regard to subjective ratings and electrodermal activity. Yohimbine did not potentiate the response to the tasks in the patients. In controls, heart rate during the mental arithmetic task, but not during rest, was increased after yohimbine. In contrast to other yohimbine challenge studies no panic attacks were observed. It is hypothesized that the experimental design together with an instructional set that reduces expectancy factors and the inclusion of structured and time-limited tasks in a challenge paradigm is able to reduce the anxiogenic effects of yohimbine.