Cardiovascular manifestations of HIV infection
Cardiovascular manifestations of HIV infection
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DOI：
10.1136/hrt.2008.161463
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发表时间：
2009-07-15
期刊：
影响因子：
5.7
通讯作者：
Hsue, Priscilla Y.
中科院分区：
文献类型：
--
作者：
Ho, Jennifer E.;Hsue, Priscilla Y.
截至2003年底，美国估计有100万人感染人类免疫缺陷病毒（HIV）或获得性免疫缺陷综合症（AIDS）。w1自1996年高效抗逆转录病毒疗法（HAART）问世以来，艾滋病毒相关死亡率大幅下降。w2然而，随着患者寿命的延长，慢性健康并发症（如心血管疾病）代表了该患者人群中日益重要的健康问题。HIV感染者心血管疾病的病因尚未完全确定，可能与病毒感染本身、HAART的使用或免疫反应的改变有关。本综述将重点关注艾滋病毒感染的心血管表现，特别强调冠心病（CHD）和心血管危险因素。
At the end of 2003, an estimated 1 million people were living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) in the USA. w1 Since the advent of highly active antiretroviral therapy (HAART) in 1996, HIV related mortality has decreased dramatically. w2 However, as patients are living longer, chronic health complications such as cardiovascular disease represent an increasing important health issue in this patient population. The aetiology of cardiovascular disease in HIV infection is not well established, and may be related to viral infection itself, the use of HAART, or altered immune responses. This review will focus on cardiovascular manifestations of HIV infection, with particular emphasis on coronary heart disease (CHD) and cardiovascular risk factors.