Necrotic cell death and 'necrostatins': now we can control cellular explosion
Necrotic cell death and 'necrostatins': now we can control cellular explosion
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DOI：
10.1016/j.tibs.2008.05.007
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发表时间：
2008-08-01
影响因子：
13.8
通讯作者：
Vanden Berghe, Tom
中科院分区：
文献类型：
--
作者：
Vandenabeele, Peter;Declercq, Wim;Vanden Berghe, Tom
受体相互作用蛋白1（RIP1）激酶活性是死亡受体诱导的坏死性细胞死亡所必需的。最近，已经证实，“坏死抑制素”通过抑制RIP1激酶活性有效地阻断肿瘤坏死因子诱导的坏死细胞死亡。这一发现支持了受体诱导的坏死，就像细胞凋亡一样，是一个受控的细胞过程的概念。此外，necrostatin正在成为评估实验性疾病模型中坏死细胞死亡贡献的重要工具。
The receptor-interacting protein 1 (RIP1) kinase activity is necessary for death-receptor-induced necrotic cell death. Recently, it has been demonstrated that 'necrostatins' efficiently block tumor necrosis factor-induced necrotic cell death through the inhibition of RIP1 kinase activity. This discovery supports the concept that receptor-induced necrosis, just like apoptosis, is a controlled cellular process. In addition, necrostatins are becoming important tools for evaluating the contribution of necrotic cell death in experimental disease models.