Social conflict drives the evolutionary divergence of quorum sensing
Social conflict drives the evolutionary divergence of quorum sensing
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DOI：
10.1073/pnas.1102923108
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发表时间：
2011-08-16
影响因子：
11.1
通讯作者：
Eldar, Avigdor
中科院分区：
文献类型：
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作者：
Eldar, Avigdor
在微生物“群体感应”（QS）通信系统中，微生物产生并响应信号分子，从而在高细胞密度下实现合作响应。许多种细菌表现出快速的、种内的、进化上的QS途径特异性差异-信号分子激活同一菌株中的同源受体，但不能激活，有时抑制其他菌株的同源受体。尽管有许多分子研究，但仍然不清楚信号分子和受体如何共同进化，是什么保持了多样性，以及是什么驱动了交叉抑制的进化。在这里，我用数学分析表明，当QS控制生产的胞外酶-“公共产品”-多样化可以很容易地演变。共同进化是通过交替的“欺骗”受体突变和“欺骗免疫”信号突变的循环来积极选择的。竞争菌株之间的兼性欺骗促进了菌株之间多样性的维持和交叉抑制的进化。我的研究结果表明，复杂的社会战略在QS系统的长期演变的作用。更一般地说，我的QS分歧模型提出了一种亲属识别形式，其中不同的亲属类型共存于非结构化人群中。
In microbial "quorum sensing" (QS) communication systems, microbes produce and respond to a signaling molecule, enabling a cooperative response at high cell densities. Many species of bacteria show fast, intraspecific, evolutionary divergence of their QS pathway specificity-signaling molecules activate cognate receptors in the same strain but fail to activate, and sometimes inhibit, those of other strains. Despite many molecular studies, it has remained unclear how a signaling molecule and receptor can coevolve, what maintains diversity, and what drives the evolution of cross-inhibition. Here I use mathematical analysis to show that when QS controls the production of extracellular enzymes-"public goods"-diversification can readily evolve. Coevolution is positively selected by cycles of alternating "cheating" receptor mutations and "cheating immunity" signaling mutations. The maintenance of diversity and the evolution of cross-inhibition between strains are facilitated by facultative cheating between the competing strains. My results suggest a role for complex social strategies in the long-term evolution of QS systems. More generally, my model of QS divergence suggests a form of kin recognition where different kin types coexist in unstructured populations.