Antimicrobial activity of chitosan nanoparticles
Antimicrobial activity of chitosan nanoparticles
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DOI：
10.1080/13102818.2022.2027816
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发表时间：
2021-01-01
影响因子：
1.4
通讯作者：
Al-Garni, Saleh Mohammed
中科院分区：
文献类型：
--
作者：
Al-Zahrani, Samiyah Saeed;Bora, Roop Singh;Al-Garni, Saleh Mohammed
壳聚糖是天然存在的脱乙酰化几丁质，特别是在真菌细胞壁和甲壳类动物壳中。壳聚糖具有生物相容性和完全生物降解性，并广泛分析了其抗菌性能。壳聚糖由于其生物相容性也被探索作为药物载体。一些研究表明，使用壳聚糖包覆由其他材料制成的纳米颗粒将有助于减少其对身体的影响，并提高其生物利用度。壳聚糖的分子量和脱乙酰度可以被改变以获得不同的物理机械性质。壳聚糖具有很强的抗真菌活性，对几种真菌菌株，包括根霉，尼日尔和链格孢。各种因素，如分子量，剂量和功能基团连接到壳聚糖已被证明是调节壳聚糖的抗真菌活性。已知壳聚糖在不需要任何化学修饰的情况下发挥抗真菌活性，然而，可以产生新的壳聚糖衍生物以靶向特定的微生物病原体。壳聚糖纳米粒是一种新型的、环境友好的药物载体，其制备方法的研究正在进行中。本文综述了近年来CSNPs在抗菌和抗真菌方面的应用，并重点介绍了壳聚糖与银等金属纳米粒子的协同作用。
Chitosan is a deacetylated chitin which is found naturally, particularly in fungal cell walls and crustacean shells. Chitosan is biocompatible and fully biodegradable and is extensively analyzed for antimicrobial property. Chitosan has also been explored as a drug carrier due to its biocompatible properties. Some studies have demonstrated that use of chitosan to coat nanoparticles made of other materials would help in reducing their impact on the body and also increase their bioavailability. The molecular weight of chitosan and the degree of deacetylation can be modified to derive different physicomechanical properties. Chitosan exhibits potent antifungal activity against several fungal strains including Rhizopus oryzae, Aspergillus niger and Alternaria alternata. Various factors such as molecular weight, dose and functional groups attached to the chitosan have been shown to modulate the antifungal activity of chitosan. Chitosan is known to exert antifungal activity without the need for any chemical modification, however, new derivatives of chitosan can be created to target specific microbial pathogens. The development of novel and ecofriendly methods of chitosan nanoparticles (CSNPs) preparation is in progress for developing chitosan as an efficient antimicrobial agent and in drug delivery system. This review is to focus on recent application of CSNPs as antibacterial and antifungal agent and to highlight the effectiveness of employing chitosan with silver and other metal nanoparticles.