FMRI "deactivation" of the posterior cingulate during generalized spike and wave
FMRI "deactivation" of the posterior cingulate during generalized spike and wave
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DOI：
10.1016/s1053-8119(03)00294-5
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发表时间：
2003-12-01
期刊：
影响因子：
5.7
通讯作者：
Jackson, GD
中科院分区：
文献类型：
--
作者：
Archer, JS;Abbott, DF;Jackson, GD
使用尖峰触发的功能磁共振成像，我们试图记录与自发性全身尖峰和慢波放电（S&W）相关的血氧水平依赖性（BOLD）活动的区域变化。研究了五名患有特发性全身性癫痫（IGE）和频繁S&W的成年患者。在3T MRI内记录EEG，允许在S&W之后采集单个全脑fMRI图像以及基线图像。在个体中捕获了4至25个尖峰和波复合体。五个个体中的四个在后扣带回中显示出显著的S& W相关BOLD信号减少（“失活”）（P < 0.001未校正）。只有在峰值最少的个体中才没有显著变化。包括所有5名受试者的组分析证实了后扣带回的fMRI失活。在个体和组分析中，在中央前沟的深处观察到一些S& W相关的BOLD信号增加。没有观察到丘脑BOLD活动发生明显的S& W相关变化。后扣带回可能在S&W和“缺席”的电临床现象中起作用。“可能性包括因果作用，扣带回活动减少促进了S&W的发生，次要作用，解释了在长时间S&W期间观察到的认知变化，或副现象。(C)2003年爱思唯尔公司All rights reserved.
Using spike-triggered fMRI, we sought to document regional changes in blood oxygen level-dependent (BOLD) activity associated with spontaneous generalised spike and slow-wave discharges (S&W). Five adult patients were studied who had idiopathic generalised epilepsy (IGE) and frequent S&W. EEG was recorded inside a 3T MRI, allowing acquisition of single, whole-brain fMRI images following S&W, as well as baseline images. Between 4 and 25 spike and wave complexes were captured in individuals. Four of the five individuals showed significant S&W-related BOLD signal reductions ("deactivation") in the posterior cingulate (P < 0.001 uncorrected). Significant changes were absent only in the individual with fewest spikes. Group analysis including all five subjects confirmed fMRI deactivation in the posterior cingulate. Some S&W-related BOLD signal increases were seen in the depths of the precentral sulci in individuals and on group analysis. No significant S&W-related changes in thalamic BOLD activity were observed. The posterior cingulate may have a role in the electroclinical phenomenon of S&W and "absence." Possibilities include a causative role, with reduced activity in the cingulate facilitating the onset of S&W, a secondary role, explaining the cognitive changes observed during prolonged S&W, or an epiphenomenon. (C) 2003 Elsevier Inc. All rights reserved.