Cell Membrane-Camouflaged Colloid Motors for Biomedical Applications
Cell Membrane-Camouflaged Colloid Motors for Biomedical Applications
复制标题
细胞膜——用于生物医学应用的伪装胶体马达
DOI：
10.1002/adtp.201800056
复制
发表时间：
2018-09-01
影响因子：
4.6
通讯作者：
He, Qiang
中科院分区：
文献类型：
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作者：
Gao, Changyong;Lin, Zhihua;He, Qiang
天然细胞膜伪装的胶体马达不仅能将周围环境能量转化为定向运动，还具备天然细胞膜的功能。它们能够自主运动，并受外源性（例如化学燃料、光、磁场和超声）和内源性（即趋化性）刺激引导。这些具有高效载药/运输能力、长血液循环时间以及抗生物污染和特异性靶向能力的生物接口胶体马达，有望为各种生物医学应用带来机遇，并被视为下一代治疗系统。在这篇进展报告中，作者强调了细胞膜包覆胶体马达研究的近期进展及其在生物医学应用方面的潜力。同时也探讨了这些胶体马达在体内应用的局限性和挑战。
Natural cell membrane-camouflaged colloid motors can not only convert the surrounding environmental energy into directed movement but also possess the functions of natural cell membranes. They can autonomously move and are guided by exogenous (e.g., chemical fuel, light, magnetic field, and ultrasound) and endogenous (i.e., chemotaxis) stimuli. These biointerfacing colloid motors with efficient drug loading/transporting capacity, prolonged blood circulation, and antibiofouling and specific targeting abilities are expected to open up opportunities for various biomedical applications and are recognized as the next-generation therapeutic systems. In this progress report, the authors highlight the recent progress in research on cell membrane-coated colloid motors, as well as their potential for biomedical applications. The limitations and challenges of these colloid motors for in vivo applications are also addressed.