PH-20 - A novel tumor marker for laryngeal cancer
PH-20 - A novel tumor marker for laryngeal cancer
复制标题
DOI：
10.1001/archotol.126.3.402
复制
发表时间：
2000-03-01
影响因子：
--
通讯作者：
Beckman, BS
中科院分区：
文献类型：
--
作者：
Godin, DA;Fitzpatrick, PC;Beckman, BS
目的：为了确定是否水平的PH-20，透明质酸酶类似于人类精子中发现，是在喉癌组织中升高。设计：在这个病例对照研究中，逆转录聚合酶链反应被用来测量水平的PH-20信使RNA组织取自喉切除术标本。设置：一所大学医学中心。患者：我们比较了11例喉癌患者和2例转移淋巴结的组织样本与正常、健康的喉组织和前列腺癌组织样本主要结果测量：通过光密度分析定量的PH-20互补DNA表达。PH-20在未照射喉癌组织中的表达显著高于正常喉组织（P
Objective: To determine whether levels of PH-20, a hyaluronidase similar to that found in human sperm, are elevated in laryngeal cancer tissue.Design: In this case-control study, reverse transcription polymerase chain reaction was used to measure levels of PH-20 messenger RNA in tissue taken from laryngectomy specimens.Setting: A university medical center.Patients: We compared tissue samples taken from 11 patients with laryngeal cancer, and from 2 metastatic lymph nodes, with samples of normal, healthy laryngeal tissue and prostate cancer tissue (positive control).Main Outcome Measure: PH-20 complementary DNA expression as quantified by densitometric analysis.Results: Expression of PH-20 was significantly higher in nonirradiated laryngeal cancer specimens than in normal laryngeal tissue (P