Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4+ T cells in thymomas
Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4+ T cells in thymomas
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DOI：
10.1182/blood.v100.1.159
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发表时间：
2002-07-01
期刊：
影响因子：
20.3
通讯作者：
Marx, A
中科院分区：
文献类型：
--
作者：
Ströbel, P;Helmreich, M;Marx, A
重症肌无力（MG）是胸腺瘤的主要副肿瘤表现，可能与胸腺瘤成熟和输出潜在自身反应性T细胞的能力有关。为什么有些胸腺瘤是MG相关的（MG+），而另一些不是（MG-）还不清楚。我们通过荧光激活细胞分选分析比较9例MG（+）和13例MG（-）胸腺瘤中瘤内幼稚成熟CD 45 RA+胸腺细胞的百分比来解决这个问题。我们的研究结果表明，肿瘤内的幼稚CD 4 T细胞存在于所有MG（+）胸腺瘤和一个MG（-）胸腺瘤的发展MG仅2个月后手术。相比之下，所有13例MG（-）胸腺瘤中幼稚CD 4（+）T细胞的百分比均显著降低（P
Myasthenia gravis (MG) is the leading paraneoplastic manifestation of thymomas and is probably related to the capacity of thymomas to mature and export potentially autoreactive T cells. Why some thymomas are MG associated (MG+) and others are not (MG-) has been unclear. We addressed this question by comparing the percentages of intratumorous naive mature CD45RA+ thymocytes in 9 MG(+) and in 13 MG(-) thymomas by fluorescence-activated cell sorting analysis. Our results show that intratumorous naive CD4 T cells were present in all MG(+) thymomas and in one MG(-) thymoma with the development of MG only 2 months after surgery. By contrast, the percentage of naive CD4(+) T cells was significantly reduced in all 13 MG(-) thymomas (P