Taking a bite: Amoebic trogocytosis in Entamoeba histolytica and beyond.
Taking a bite: Amoebic trogocytosis in Entamoeba histolytica and beyond.
复制标题
DOI：
10.1016/j.mib.2015.07.009
复制
发表时间：
2015-12
影响因子：
5.4
通讯作者：
Ralston KS
中科院分区：
文献类型：
--
作者：
Ralston KS
溶组织内阿米巴是一种腹泻病原体，能够造成严重的宿主组织损伤。这种生物体具有接触依赖性细胞杀伤活性，这可能是组织损伤的主要原因。最近显示，溶组织内阿米巴滋养体能够摄取人类活细胞碎片。事实证明，这个被称为阿米巴吞噬作用的过程有助于细胞杀伤。离体和 3-D 细胞培养方法的最新进展揭示了溶组织内阿米巴破坏组织的机制，使阿米巴吞噬作用能够置于组织损伤的其他宿主和病原体介质的背景下。除了与阿米巴病发病机制相关之外，人们还逐渐认识到细胞间蚕食发生在从原生动物到哺乳动物的许多生物体中。
Entamoeba histolytica is a diarrheal pathogen with the ability to cause profound host tissue damage. This organism possesses contact-dependent cell killing activity, which is likely to be a major contributor to tissue damage. E. histolytica trophozoites were recently shown to ingest fragments of living human cells. It was demonstrated that this process, termed amoebic trogocytosis, contributes to cell killing. Recent advances in ex vivo and 3-D cell culture approaches have shed light on mechanisms for tissue destruction by E. histolytica, allowing amoebic trogocytosis to be placed in the context of additional host and pathogen mediators of tissue damage. In addition to its relevance to pathogenesis of amoebiasis, an appreciation is emerging that intercellular nibbling occurs in many organisms, from protozoa to mammals.