Long-term consumption of red wine does not modify intestinal absorption or status of zinc and copper in rats
Long-term consumption of red wine does not modify intestinal absorption or status of zinc and copper in rats
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DOI：
10.1093/jn/130.5.1309
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发表时间：
2000-05-01
影响因子：
4.2
通讯作者：
Mazur, A
中科院分区：
文献类型：
--
作者：
Coudray, C;Tressol, JC;Mazur, A
红葡萄酒含有许多成分，如多酚和乙醇，可能会影响矿物质的吸收。我们报告的研究，在大鼠模型，旨在调查在何种程度上短期和长期摄入的红葡萄酒或乙醇可能会影响Zn-67和Cu-65在大鼠的吸收。将大鼠（n = 96）分为三组，对照组接受软化水，对照组接受用水稀释的红酒（v/v）和乙醇组接受6%乙醇，每组一半用于短期研究;其他用于长期研究。经过3天（短期研究）或28天（长期研究）的饮料消费，大鼠灌胃2吨的溶液含有2027 nmol Zn-67和902 nmol Cu-65。随后，3-D尿液和粪便收集和分析的总和同位素锌和铜。在长期研究中，还对血液、胫骨和肝脏进行了采样，以评估矿物质状态。无论是短期还是长期摄入红酒都不会改变Zn-67或Cu-65的吸收。与此相反，长期（但不是短期）乙醇消费显着增加了Zn-67和Cu-65的吸收与对照组和红葡萄酒组相比。长期饮用乙醇或红葡萄酒不会影响血液或组织中的锌或铜水平。总之，短期或长期饮用红葡萄酒对大鼠肠道吸收或锌和铜的组织水平没有负面影响。
Red wines contain many components such as polyphenols and ethanol that may influence mineral absorption. We report on studies in a rat model that were designed to investigate the extent to which short- and long-term intake of red wine or ethanol may influence Zn-67 and Cu-65 absorption in rats. Rats (n = 96) were divided into three groups, a control group that received demineralized water, a group that received red wine diluted with water (v/v) and an ethanol group that received 6% ethanol, Half of each group was used for the short-term study; the others were used for the long-term study. After 3 d (short-term study) or 28 d (long-term study) of beverage consumption, the rats were gavaged with 2 mt of solution containing 2027 nmol Zn-67 and 902 nmol Cu-65. Subsequently, 3-d urinary and fecal collections were performed and analyzed for total and isotopic Zn and Cu. In the long-term study, blood, tibia and liver were also sampled for mineral status assessment. Neither short- nor long-term intake of red wine altered Zn-67 or Cu-65 absorption. In contrast, long-term (but not short-term) ethanol consumption significantly increased both Zn-67 and Cu-65 absorption compared with the control and red wine groups. The long-term consumption of ethanol or red wine did not affect blood or tissue Zn or Cu levels. In conclusion, short- or long-term consumption of red wine did not have a negative effect on intestinal absorption or tissue levels of zinc and Cu in rats.