A meta-analysis of randomized control trials of surgical methods with osteosarcoma outcomes.
A meta-analysis of randomized control trials of surgical methods with osteosarcoma outcomes.
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DOI：
10.1186/s13018-016-0500-0
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发表时间：
2017-01-13
影响因子：
2.6
通讯作者：
Fu P
中科院分区：
文献类型：
--
作者：
He X;Gao Z;Xu H;Zhang Z;Fu P
骨肉瘤是一种高度恶性肿瘤，关于骨肉瘤患者残肢或截肢后的生存和功能恢复的研究结果相互矛盾。在本研究中，我们通过荟萃分析比较了保肢手术（LSS）和截肢对骨肉瘤患者临床结果的影响。骨肉瘤患者生存率收集自CNKI、MEDLINE、EMBASE、Cochrane数据库、谷歌Scholar等网站截至2016年4月30日的研究报告。纳入文章的质量由两名独立审稿人评估。根据术后存活率，分析残肢手术与截肢患者的差异。根据选择标准纳入了10篇文章。这些研究共纳入1343名患者。结果显示，残肢保留手术与局部复发截肢无显著性差异；然而，肢体保留手术患者的5年总生存率更高。LSS可提高5年生存率和生存率，且不增加局部复发风险。本研究为残肢手术治疗骨肉瘤提供了更多的证据。
Osteosarcoma is a high malignant neoplasm, and conflicting findings have been reported on the survival and function recovery of osteosarcoma patients experiencing limb salvage or amputation. In the present study, we compared limb salvage surgery (LSS) with amputation in clinical outcomes of osteosarcoma patients by a meta-analysis. The survival rate of osteosarcoma patients was collected from research reports from CNKI, MEDLINE, EMBASE, the Cochrane Database, and Google Scholar till April 30, 2016. The quality of including articles was evaluated by two independent reviewers. Differences between patients undergoing limb salvage surgery and amputation were analyzed based on postoperative survival rates. Ten articles were included according to selection criteria. There were 1343 patients in total from these studies. Our results showed that there was no significant difference between limb salvage surgery and amputation according to local recurrence; however, patients with limb salvage surgery had a higher 5-year overall survival. LSS results in higher 5-year survival rates and better survival, while not increasing the risk of local recurrence. This study provided more evidences to support limb salvage surgery as a considerable treatment of osteosarcoma patients.