The localization of monoaminergic blood-brain barrier mechanisms.
The localization of monoaminergic blood-brain barrier mechanisms.
复制标题
单胺能血脑屏障机制的定位。
DOI：
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发表时间：
1966
影响因子：
21.1
通讯作者：
E. Rosengrenn
中科院分区：
文献类型：
--
作者：
Å. Bertler;B. Falck;C. Owman;E. Rosengrenn
用化学测定和组织化学定位相结合的方法研究了多巴和多巴胺进入小鼠脑的通路。L-多巴，而不是D-多巴或多巴胺，很容易渗透到毛细血管壁。这些含有多巴脱羧酶和单胺氧化酶，它们阻碍左旋多巴进一步进入大脑。没有一种化合物可以进入脑内非毛细血管的内皮衬里。自由通过发生在外周组织以及已知位于血脑屏障之外的脑区域中。
结果表明在血管水平存在专门的脑屏障机制。
The passage of dopa and dopamine into the mouse brain has been studied with a combination of chemical determination and histochemical localization of certain monoamines and their precursors. L-Dopa, but not D-dopa or dopamine, readily penetrates into the capillary walls. These contain dopa decarboxylase and MAO, which impede the further passage of L-dopa into the brain. None of the compounds can pass into the endothelial lining of noncapillary intracerebral vessels. A free passage occurs in peripheral tissues as well as in brain areas known to be located beyond the blood-brain barrier.
The results demonstrate the existence of specialized brain barrier mechanisms at the vascular level.