Alginate based photothermal cryogels boost ferrous-supply for enhanced antibacterial chemodynamic therapy and accelerated wound healing
Alginate based photothermal cryogels boost ferrous-supply for enhanced antibacterial chemodynamic therapy and accelerated wound healing
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基于藻酸盐的光热冷冻凝胶可增加铁的供应，以增强抗菌化学动力学治疗并加速伤口愈合
DOI：
10.1016/j.ijbiomac.2023.123473
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发表时间：
2023
影响因子：
8.2
通讯作者：
Yun Liu
中科院分区：
文献类型：
--
作者：
Jia Chen;Yu Xia;Qian Lan;Min Hu;Yueying Xu;Quanxin Wu;Xinguang Liu;Yun Liu
失控的出血是院前死亡的主要原因。鉴于止血伤口敷料在院前急救中的重要性，需要新型复合材料来实现快速止血、阻力可忽略不计的协同细菌消融和加速伤口愈合。本文通过海藻酸钠（SA）和单宁酸（TA）与Fe3+离子同时交联制备了多功能SCTF冷冻凝胶。结果，制备的 SCTF 冷冻凝胶由 Fe3+/TA 基金属酚网络（MPN）和 Fe3+/SA 基胶原蛋白 3D 骨架（CA）组成。 MPNs赋予冰凝胶光热效应、光热增强Fenton活性以及TA和Fe2+的pH/光热双响应释放特性，有利于抗菌能力。由于其固有的高孔隙率，体外和体内实验表明SCTF冷冻凝胶具有良好的止血能力。此外，协同光热疗法（PTT）、化学动力学疗法（CDT）和pH/光热响应化疗显着增强了SCTF冰凝胶的体外和体内杀菌功效。最终，它们出色的加速愈合作用通过动物实验得到证实，这归因于CA和TA的存在。因此，所开发的复合材料可以为未来开发多功能伤口敷料的临床应用提供新策略。
Uncontrolled hemorrhage is a main cause of pre-hospital death. Given the importance of hemostatic wound dressings in pre-hospital emergency treatment, novel composite materials are required for fast hemostasis, synergistic bacterial ablation with negligible resistance and wound healing acceleration. Herein, multifunctional SCTF cryogels were fabricated by the simultaneous cross-linking of sodium alginate (SA) and tannic acid (TA) with Fe3+ions. As a result, the prepared SCTF cryogels consisted of Fe3+/TA-based metal phenolic networks (MPNs) and Fe3+/SA-based 3D skeleton for collagen (CA). MPNs endowed the cryogels with photothermal effect, photothermal-enhanced Fenton activity and pH/photothermal dual-responsive release property of TA and Fe2+, which were beneficial for the antibacterial capacity. Due to the intrinsic high porosity,in vitroandin vivoassays demonstrated that SCTF cryogels possessed good hemostatic capacity. Moreover, the synergistic photothermal therapy (PTT), chemodynamic therapy (CDT) and pH/photothermal responsive chemo-therapy dramatically enhanced the bactericidal efficacy of SCTF cryogels bothin vitroandin vivo. Eventually, their outstanding healing-accelerating effects were confirmedviaanimal experiments, which were attributed to the presence of CA and TA. Therefore, the developed composite materials could offer new strategy on exploiting multifunctional wound dressing for clinical applications in the future.