The 20,000-dalton structural variant of human growth hormone: lack of some early insulin-like effects.
The 20,000-dalton structural variant of human growth hormone: lack of some early insulin-like effects.
复制标题
人类生长激素的 20,000 道尔顿结构变体：缺乏一些早期胰岛素样作用。
DOI：
10.1016/0006-291x(79)91947-8
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发表时间：
1979
影响因子：
3.1
通讯作者：
U. Lewis
中科院分区：
文献类型：
--
作者：
L. Frigeri;S. M. Peterson;U. Lewis
与人生长激素的主要形式相反，20，000-道尔顿（20 K）的生长激素变体在注射到禁食的垂体切除大鼠体内后1小时，血清葡萄糖或游离脂肪酸均未降低。此外，该变体在5小时后未引起血清游离脂肪酸升高。利用垂体切除大鼠附睾脂肪组织的体外实验表明，20 K不能加速葡萄糖的利用，如葡萄糖摄取和CO2形成所测量的。数据显示，这种形式，即使促进生长，缺乏一些归因于生长激素的代谢特性。我们得出结论，胰岛素样作用不一定是促进生长活性的先决条件。
In contrast to the major form of human growth hormone the 20,000-dalton (20K) variant of the hormone produced no decrease in either serum glucose of free fatty acids one hour after injection into fasted, hypophysectomized rats. Furthermore, the variant caused no rise in serum free fatty acids after 5 hours. In vitro experiments utilizing epididymal adipose tissue from hypophysectomized rats indicated that 20K was unable to accelerate glucose utilization as measured by glucose uptake and CO 2 formation. The data show that this form, even though growth promoting, lacks some of the metabolic properties attributed to growth hormone. We conclude that an insulin-like effect is not necessarily a prerequisite for growth promoting activity.