Advances in cancer pain from bone metastasis.
Advances in cancer pain from bone metastasis.
复制标题
骨转移癌痛的研究进展
DOI：
10.2147/dddt.s87568
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fu CY
中科院分区：
文献类型：
--
作者：
Zhu XC;Zhang JL;Ge CT;Yu YY;Wang P;Yuan TF;Fu CY
随着癌症诊断和治疗技术的进步，癌症患者的生存率延长。如何提高癌症患者的生活质量问题日益突出。疼痛，尤其是骨痛，是恶性肿瘤患者最常见的症状，严重影响癌症患者的生活质量。近年来随着癌痛动物模型的发展，如小鼠股骨、肱骨、跟骨、大鼠胫骨等癌痛动物模型的建立，使癌痛的研究有了突破性进展。几种癌痛相关动物模型的建立为在体内研究癌痛的分子机制提供了新的平台。本文重点介绍骨转移癌性疼痛的研究进展、癌性疼痛的机制以及动物模型中癌性疼痛的药物治疗。
With the technological advances in cancer diagnosis and treatment, the survival rates for patients with cancer are prolonged. The issue of figuring out how to improve the life quality of patients with cancer has become increasingly prominent. Pain, especially bone pain, is the most common symptom in malignancy patients, which seriously affects the life quality of patients with cancer. The research of cancer pain has a breakthrough due to the development of the animal models of cancer pain in recent years, such as the animal models of mouse femur, humerus, calcaneus, and rat tibia. The establishment of several kinds of animal models related to cancer pain provides a new platform in vivo to investigate the molecular mechanisms of cancer pain. In this review, we focus on the advances of cancer pain from bone metastasis, the mechanisms involved in cancer pain, and the drug treatment of cancer pain in the animal models.