Roles of matrix metalloproteinases in tumor metastasis and angiogenesis.
Roles of matrix metalloproteinases in tumor metastasis and angiogenesis.
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DOI：
10.5483/bmbrep.2003.36.1.128
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发表时间：
2003-01
期刊：
影响因子：
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通讯作者：
Sang-Oh Yoon;Soo-Jin Park;C. Yun;A. Chung
中科院分区：
文献类型：
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作者：
Sang-Oh Yoon;Soo-Jin Park;C. Yun;A. Chung
基质金属蛋白酶(MMPs)、锌依赖的蛋白水解酶、裂解细胞外基质(ECM：胶原、层粘连蛋白、纤维连接蛋白等)以及非基质底物(生长因子、细胞表面受体等)。MMPs的失控与多种疾病有关，如肿瘤转移、类风湿性关节炎、牙周病等。转移是癌症患者死亡的主要原因。本文就MMPs在肿瘤转移中的作用作一综述。转移过程包括一系列相互关联的、连续的步骤，这些步骤涉及多个宿主-肿瘤的相互作用。具体地说，MMPs参与肿瘤转移的多个环节。这些包括肿瘤的侵袭、迁移、宿主免疫逃逸、外渗、血管生成和肿瘤生长。因此，如果没有MMPs，肿瘤细胞就不能成功转移。MMPs的活性在基因转录水平上受到严格调控，通过蛋白分解激活酶原，并受到内源性抑制物、金属蛋白酶组织抑制物(TIMP)和RECK的抑制。本文对MMPs的详细规定进行了综述。
Matrix metalloproteinases (MMPs), zinc dependent proteolytic enzymes, cleave extracellular matrix (ECM: collagen, laminin, firbronectin, etc) as well as non-matrix substrates (growth factors, cell surface receptors, etc). The deregulation of MMPs is involved in many diseases, such as tumor metastasis, rheumatoid arthritis, and periodontal disease. Metastasis is the major cause of death among cancer patients. In this review, we will focus on the roles of MMPs in tumor metastasis. The process of metastasis involves a cascade of linked, sequential steps that involve multiple host-tumor interactions. Specifically, MMPs are involved in many steps of tumor metastasis. These include tumor invasion, migration, host immune escape, extravasation, angiogenesis, and tumor growth. Therefore, without MMPs, the tumor cell cannot perform successful metastasis. The activities of MMPs are tightly regulated at the gene transcription levels, zymogen activation by proteolysis, and inhibition of active forms by endogenous inhibitors, tissue inhibitor of metalloproteinase (TIMP), and RECK. The detailed regulations of MMPs are described in this review.