Sleep Spindles and Hippocampal Functional Connectivity in Human NREM Sleep
Sleep Spindles and Hippocampal Functional Connectivity in Human NREM Sleep
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DOI：
10.1523/jneurosci.5660-10.2011
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发表时间：
2011-07-13
影响因子：
5.3
通讯作者：
Czisch, Michael
中科院分区：
文献类型：
--
作者：
Andrade, Katia C.;Spoormaker, Victor I.;Czisch, Michael
我们研究了人在清醒状态和非快速眼动睡眠状态下的海马区功能连接。健康青年受试者在静息至深度睡眠的1.5T条件下同时进行脑电和功能磁共振成像(FMRI)检测。提取代表独特睡眠阶段(即，觉醒、睡眠阶段1和2、或慢波睡眠)的连续5分钟历元。基于细胞构筑概率图，提取了海马结构(HF)亚区域(腺角、齿状回和下丘)的fMRI时间序列。我们观察到HF功能偶联随睡眠阶段的变化。在清醒和轻睡眠阶段，HF在默认模式网络(DMN)中被整合到不同的强度，但在慢波睡眠中不被整合。在睡眠阶段2观察到HF和新皮质之间最强的功能连接(与慢波睡眠和清醒相比)。在睡眠阶段2，我们观察到睡眠纺锤体的出现和HF功能连接的强烈交互作用，在纺锤体期HF/新皮质连接性增加。此外，在清醒状态下，杏仁角显示出与DMN最强的功能连接，而在睡眠第二阶段，下丘脑主导着海马区与额叶脑区的功能连接。在睡眠第二阶段，HF和新皮质区域之间的连接增加，表明可能的全局信息传输能力增强，而慢波睡眠中的连接反映了一种最适合分离信息再处理的功能系统。我们的数据可能与区分睡眠阶段对神经可塑性的特定贡献有关，正如睡眠依赖记忆巩固所提出的那样。
We investigated human hippocampal functional connectivity in wakefulness and throughout non-rapid eye movement sleep. Young healthy subjects underwent simultaneous EEG and functional magnetic resonance imaging (fMRI) measurements at 1.5 T under resting conditions in the descent to deep sleep. Continuous 5 min epochs representing a unique sleep stage (i.e., wakefulness, sleep stages 1 and 2, or slow-wave sleep) were extracted. fMRI time series of subregions of the hippocampal formation (HF) (cornu ammonis, dentate gyrus, and subiculum) were extracted based on cytoarchitectonical probability maps. We observed sleep stage-dependent changes in HF functional coupling. The HF was integrated to variable strength in the default mode network (DMN) in wakefulness and light sleep stages but not in slow-wave sleep. The strongest functional connectivity between the HF and neocortex was observed in sleep stage 2 (compared with both slow-wave sleep and wakefulness). We observed a strong interaction of sleep spindle occurrence and HF functional connectivity in sleep stage 2, with increased HF/neocortical connectivity during spindles. Moreover, the cornu ammonis exhibited strongest functional connectivity with the DMN during wakefulness, while the subiculum dominated hippocampal functional connectivity to frontal brain regions during sleep stage 2. Increased connectivity between HF and neocortical regions in sleep stage 2 suggests an increased capacity for possible global information transfer, while connectivity in slow-wave sleep is reflecting a functional system optimal for segregated information reprocessing. Our data may be relevant to differentiating sleep stage-specific contributions to neural plasticity as proposed in sleep-dependent memory consolidation.