Maturation of the human brain and epilepsy.
Maturation of the human brain and epilepsy.
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DOI：
10.1016/b978-0-444-52898-8.00007-0
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Dulac, Olivier
中科院分区：
文献类型：
--
作者：
Holmes, Gregory L;Milh, M D Mathieu;Dulac, Olivier
All features of childhood epilepsy are intimately related to brain development. The clinical EEG features of seizures are closely related to developmental changes in cell growth, synapse formation, and myelination. The immature brain is highly excitable due to the depolarizing effects of GABA, overexpression of glutamatergic receptors, and lack of efficient inhibitory control. Seizures have an age-specific effect on brain development.Whereas early life seizures rarely result in cell loss, they can induce changes in synapse organization and receptor physiology.
