Mechanism of hypokalemia in magnesium deficiency
Mechanism of hypokalemia in magnesium deficiency
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DOI：
10.1681/asn.2007070792
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发表时间：
2007-10-01
影响因子：
13.6
通讯作者：
Kuo, Elizabeth
中科院分区：
文献类型：
--
作者：
Huang, Chou-Long;Kuo, Elizabeth
镁缺乏常与低钾血症有关。伴随的镁缺乏加重低钾血症，并使其对钾治疗无效。本文综述了镁缺乏通过增加远端钾分泌而加重钾消耗的文献。由镁缺乏引起的细胞内镁减少，释放镁介导的ROMK通道抑制并增加钾分泌。然而，镁缺乏本身并不一定会导致低钾血症。远端钠输送增加或醛固酮水平升高可能是加重镁缺乏时钾消耗的必要条件。
Magnesium deficiency is frequently associated with hypokalemia. Concomitant magnesium deficiency aggravates hypokalemia and renders it refractory to treatment by potassium. Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency.