Six conformers of neutral aspartic acid identified in the gas phase.
Six conformers of neutral aspartic acid identified in the gas phase.
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在气相中鉴定出中性天冬氨酸的六种构象异构体。
DOI：
10.1039/b926520a
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
José L. Alonso
中科院分区：
文献类型：
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作者：
M. Sanz;Juan C. López;José L. Alonso
天冬氨酸是具有两个羧基的最简单的氨基酸，首次在气相中探索了其多构象景观。采用激光烧蚀法对固体天冬氨酸（mp . > ~ 300℃）进行汽化，并在超音速射流中膨胀，利用傅里叶变换微波光谱法获得了不同构象的旋转光谱。六种不同的构象通过其不同的旋转和（14）N核四极耦合常数被最终确定。构象的相对稳定性取决于在两个羧基和氨基之间建立的不同分子内氢键的微妙平衡。
The multiconformational landscape of the proteogenic amino acid aspartic acid, the simplest amino acid with two carboxylic groups, has been explored for the first time in the gas phase. Solid aspartic acid (m.p. > 300 degrees C) was vaporized by laser ablation and expanded in a supersonic jet where rotational spectra of various conformers were obtained by Fourier transform microwave spectroscopy. Six different conformers have been conclusively identified by their distinct rotational and (14)N nuclear quadrupole coupling constants. The relative stability of the conformers rests on a delicate balance of the different intramolecular hydrogen bonds established between the two carboxylic groups and the amino group.