The relationship between depression and frailty syndrome: a systematic review
The relationship between depression and frailty syndrome: a systematic review
复制标题
DOI：
10.1080/13607863.2014.967174
复制
发表时间：
2015-09-02
影响因子：
3.4
通讯作者：
Cauli, Omar
中科院分区：
文献类型：
--
作者：
Buigues, Cristina;Padilla-Sanchez, Celia;Cauli, Omar
目的：虚弱是一种老年综合征，其特征在于可识别的身体变化的临床表现，例如肌肉质量和力量、能量和运动耐量的损失以及生理储备减少。虚弱和抑郁症状是老年人面临的常见问题，可能与此相关。目前尚不清楚抑郁症是否促进了虚弱综合征的出现，或者反之亦然，或者这两种症状在同一个体中独立共存。我们在几个数据库中进行了搜索（Embase，PubMed，CINAHL，Scopus，（PsycINFO）2003年11月至2014年2月期间发表的关于65岁及以上人群的虚弱综合征和抑郁症的论文，以及对检索到的文章进行筛选，以识别在初始检索中可能遗漏的文章。两个独立的评论者提取的患病率和共同发生的脆弱和抑郁症的老年人和脆弱的标准之间的抑郁症patients.Results：抑郁症和脆弱的描述性信息发生在一个显着比例的体弱老年人。在这两个综合征的共同病理生理学改变和生物标志物最近已被描述。结论：这两个综合征之间的因果关系的研究显然是必要的，在未来。
Objectives: Frailty is a geriatric syndrome characterised by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Frailty and depressive symptoms are common issues facing older adults and may be associated. It is not clear if the depression facilitates the appearance of frailty syndrome or vice versa or these two coexist independently in the same individuals.Method: We performed searches in several databases (Embase, PubMed, CINAHL, Scopus, and PsycINFO) papers published between November 2003 to February 2014 about frailty syndrome and depression in people aged 65 and older published and the reference lists of from the articles retrieved were pearled in order to identify any which may have been missed in the initial search. Two independent reviewers extracted descriptive information on the prevalence and co-occurrence of frailty and depression in older individuals and of frailty criteria among depressed patients.Results: Depression and frailty occur in a significant proportion of frail older individuals. Common pathophysiological alterations and biomarkers in the two syndromes have been recently described.Conclusion: Studies on the causal relationship between the two syndromes are clearly necessary in the future.