The determination of in vitro pingyangmycin hydrochloride plasma protein binding by microdialysis.
The determination of in vitro pingyangmycin hydrochloride plasma protein binding by microdialysis.
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发表时间：
2007-02
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通讯作者：
Z. Gao;P. Ding;H. Xu;L. Zhang;J. Wei;D. Chen
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作者：
Z. Gao;P. Ding;H. Xu;L. Zhang;J. Wei;D. Chen
微透析采样用于研究pingyangmmycin盐酸盐（PYM）与Canis Famishis血液中血浆蛋白的结合。在一系列PYM浓度中评估了体外血浆蛋白结合级分。结果显示，蛋白质结合随浓度升高而降低。使用SCATCHARD分析和Klotz图对数据进行了分析。结果表明，Scatchard图和Klotz图是线性的，具有良好的相关系数，表明实验数据与理论方程式有很好的一致性。
Microdialysis sampling was used to study the binding of pingyangmycin hydrochloride (PYM) to plasma proteins in canis familiaris blood. In vitro plasma protein binding fractions were evaluated in a series of PYM concentration. The results showed decreased protein binding with increased concentration. The data was analyzed using the Scatchard analysis and Klotz plot. The results showed that the Scatchard plot and Klotz plot were linear with good correlation coefficient, indicating a good agreement of the experimental data to the theoretical equation.