The role and regulation of cardiac angiotensin-converting enzyme for noninvasive molecular imaging in heart failure.
The role and regulation of cardiac angiotensin-converting enzyme for noninvasive molecular imaging in heart failure.
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DOI：
10.1007/bf02938342
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发表时间：
2007-04-01
影响因子：
3.7
通讯作者：
Dilsizian, Vasken
中科院分区：
文献类型：
--
作者：
Aras, Omer;Messina, Steven A;Dilsizian, Vasken
充血性心力衰竭是一种病理状态，其特征是左心室收缩力进行性下降，从而导致心输出量下降。有令人信服的临床和实验证据表明，肾素-血管紧张素系统（RAS）及其主要效应肽，血管紧张素II，与间质纤维化，心脏重塑和心力衰竭的病理生理学。除了传统的内分泌或循环RAS，一个活跃的组织RAS的特点。组织血管紧张素转换酶和局部合成的血管紧张素II，例如，通过糜酶，发挥局部营养作用，调节基因表达，调节肌细胞和非肌细胞的生长和增殖。组织RAS的存在为靶向成像提供了机会，这对于指导医学治疗可能具有相当大的价值。
Congestive heart failure is a pathologic condition characterized by progressive decrease in left ventricular contractility and consequent decline of cardiac output. There is convincing clinical and experimental evidence that the renin-angiotensin system (RAS) and its primary effector peptide, angiotensin II, are linked to the pathophysiology of interstitial fibrosis, cardiac remodeling, and heart failure. In addition to the traditional endocrine or circulating RAS, an active tissue RAS has been characterized. Tissue angiotensin-converting enzyme and locally synthesized angiotensin II, for example, by chymase, exert local trophic effects that modulate gene expression, which regulates growth and proliferation in both myocytes and nonmyocytes. The existence of the tissue RAS offers an opportunity for targeted imaging, which may be of considerable value for guiding medical therapy.