New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond.
New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond.
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NFIL3 BZIP转录因子癌症，代谢及其他地区的新领域。
DOI：
10.15190/d.2014.7
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Parsons R
中科院分区：
文献类型：
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作者：
Keniry M;Dearth RK;Persans M;Parsons R
bZIP转录因子NFIL3（核因子白细胞介素3调节，也称为E4结合蛋白4，E4BP4）调节从昼夜节律到细胞活力的多种生物过程。近年来，NFIL3在免疫信号转导、肿瘤、衰老和代谢等方面发挥着重要作用。阐明受NFIL3影响的信号通路及其靶向、抑制或激活的调控机制对于更清楚地了解其在疾病和正常过程中的生理作用至关重要。本文将讨论NFIL3介导的CEBPb和FOXO 1激活基因的转录调控和信号转导的最新进展和新出现的问题。
The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPb and FOXO1 activated genes and signal transduction.