LIPIDS, LIPOPROTEINS, TRIGLYCERIDE CLEARANCE, AND CYTOKINES IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION AND THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME
LIPIDS, LIPOPROTEINS, TRIGLYCERIDE CLEARANCE, AND CYTOKINES IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION AND THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME
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DOI：
10.1210/jcem.74.5.1373735
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发表时间：
1992-05-01
影响因子：
5.8
通讯作者：
FEINGOLD, KR
中科院分区：
文献类型：
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作者：
GRUNFELD, C;PANG, MY;FEINGOLD, KR
感染引起脂质代谢紊乱，可能由细胞因子介导。因此，我们研究了三组中的血浆脂质、脂蛋白、甘油三酯（TG）代谢和血清细胞因子：艾滋病患者血浆TG和FFA升高，而血浆胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆载脂蛋白-A-1（Apo-A-1）、低密度脂蛋白（LDL）胆固醇和Apo-B-100水平降低。艾滋病患者的TG水平升高主要是由于正常组成的极低密度脂蛋白升高;此外，LDL和HDL富含TG。在HIV+患者中，TG和FFA没有增加，但总胆固醇、HDL胆固醇、Apo-A-1和Apo-B-100显著降低。血浆TG与IFN-α水平显著相关（r = 0.477; P < 0.01），而与肿瘤坏死因子、C反应蛋白、结合珠蛋白和P-24抗原无相关性。此外，循环IFN-α水平与血浆胆固醇、HDL胆固醇、Apo-A-1、LDL胆固醇、Apo-B-100或FFA之间没有关系。AIDS和HIV+患者的TG清除时间和肝素后脂肪酶显著降低。AIDS和HIV+患者血清IFN-α水平与TG清除时间呈强相关（r = 0.783; P < 0.001）。总之，AIDS和HIV+患者胆固醇和含胆固醇脂蛋白（包括HDL）的降低先于高甘油三酯血症的出现，与IFN-α或TG水平无关。我们的数据提出了这样一种可能性，即随着艾滋病的发展，随后IFN-α的增加可能部分通过降低TG的清除而导致血浆TG水平的升高。
Infection causes disturbances in lipid metabolism that may be mediated by cytokines. Therefore we studied plasma lipids, lipoproteins, triglyceride (TG) metabolism, and serum cytokines in three groups: patients with the acquired immunodeficiency syndrome (AIDS) without active secondary infection, patients with evidence of human immunodeficiency virus infection but without clinical AIDS (HIV+), and controls.Plasma TGs and FFA were increased in AIDS, while plasma cholesterol, high density lipoprotein (HDL) cholesterol, apolipoprotein-A-1 (Apo-A-1), low density lipoprotein (LDL) cholesterol, and Apo-B-100 levels were decreased. Increased TG levels in AIDS were primarily due to increases in very low density lipoprotein of normal composition; in addition, LDL and HDL were TG enriched. In HIV+, TGs and FFA were not increased, but total cholesterol, HDL cholesterol, Apo-A-1, and Apo-B-100 were significantly decreased.Interferon-a (IFN-alpha) and C-reactive protein levels were increased in AIDS, but tumor necrosis factor and haptoglobin levels were not. There was a significant correlation between plasma TGs and IFN-alpha levels (r = 0.477; P < 0.01), but not between TGs and tumor necrosis factor, C-reactive protein, haptoglobin, or P-24 antigen. In addition, there was no relationship between circulating IFN-alpha levels and plasma cholesterol, HDL cholesterol, Apo-A-1, LDL cholesterol, Apo-B-100, or FFA. TG clearance time and postheparin lipase were significantly decreased in AIDS and HIV+. There was a strong correlation between serum IFN-alpha levels and TG clearance time in AIDS and HIV+ (r = 0.783; P < 0.001).In summary, decreases in cholesterol and cholesterol containing lipoproteins (including HDL) in both AIDS and HIV+ precede the appearance of hypertriglyceridemia and are not related to IFN-alpha or TG levels. Our data raise the possibility that with development of AIDS, subsequent increases in IFN-alpha may contribute to increases in plasma TG levels in part by decreasing the clearance of TG.