Recruitment and participation in clinical trials: Socio-demographic, rural/urban, and health care access predictors
Recruitment and participation in clinical trials: Socio-demographic, rural/urban, and health care access predictors
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DOI：
10.1016/j.cdp.2005.12.001
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Mishra, SI
中科院分区：
文献类型：
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作者：
Baquet, CR;Commiskey, P;Mishra, SI
背景：少数族裔，特别是非裔美国人和服务不足的农村人口，招募和参与临床试验的比例很低。这份报告考察了成年马里兰人临床试验招募和参与的预测因素。方法：采用横断面设计对居住在马里兰州24个司法管辖区中13个司法管辖区的5154名成年人(18岁及以上)进行调查，其中包括巴尔的摩市市区以及马里兰州西部和东海岸的农村地区。这项调查在2001年12月至2003年3月期间进行。使用计算机辅助电话访问和随机数字拨号程序。主要因变量包括“曾经被要求参与”(即，招募)和“参与”临床试验。结果：11.1%的受试者参与了临床试验。此外，59.4%的被招募参加临床试验的受访者实际上参与了临床试验。在被招募参加临床试验的受访者中。黑人和中等收入受访者实际参与临床试验的可能性显著降低，而从医疗保健提供者那里获得临床试验信息、了解临床试验的受访者以及那些有时间承诺的受访者参与临床试验的可能性显著增加。结论：这些结果表明，在招募少数族裔和农村地区居民进行临床试验方面存在严重差距。这些发现为为普通公众和卫生保健专业人员制定和实施以社区为基础的教育方案提供了基础，并加强了以社区为基础的临床试验的可用性，特别是在该州的农村地区。(C)2006年国际预防肿瘤学学会。爱思唯尔有限公司出版。保留所有权利。
Background: Recruitment and participation in clinical trials by minorities, particularly African Americans and rural underserved populations, are low. This report examines predictors of clinical trial recruitment and participation for adult Marylanders. Methods: A cross-sectional design was used to survey 5154 adults (18 years and older) residing in 13 of the 24 jurisdictions in Maryland, including urban Baltimore City, and the rural regions of Western Maryland and the Eastern Shore. The survey, conducted between December 2001 and March 2003. used Computer-Assisted Telephone Interviewing and random-digit dialing procedures. Primary dependent variables included "ever asked to participate" (i.e., recruited) and "participated" in clinical trials. Results: 11.1% of the respondents had been recruited to clinical trials. In addition, 59.4% of the respondents recruited to clinical trials actually participated in a clinical trial. Among respondents recruited to clinical trials. black and middle income respondents were significantly less likely to actually participate in clinical trials whereas, respondents who received information about clinical trials from their health care provider, who were knowledgeable about clinical trials, and those who had the time commitment were significantly more likely to participate in clinical trials. Conclusions: These results suggest serious gaps in efforts to recruit racial/ethnic minorities and residents Of rural regions into clinical trials. The findings provide the basis for the development and implementation of community-based educational programs for both the general public and health care professionals, and to enhance availability of community-based clinical trials, especially in the rural areas of the state. (c) 2006 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.