Age‐related deterioration of pyramidal cell basal dendrites in rat auditory cortex
Age‐related deterioration of pyramidal cell basal dendrites in rat auditory cortex
复制标题
大鼠听觉皮层锥体细胞基底树突与年龄相关的退化
DOI：
10.1002/cne.901710406
复制
发表时间：
1977
影响因子：
2.5
通讯作者：
D. W. Vaughan
中科院分区：
文献类型：
--
作者：
D. W. Vaughan
在一组 3 个月大的大鼠以及一组 34 和 36 个月大的大鼠中，对大鼠听觉皮层中 V 层锥体细胞的基底树突树进行了定量检查。对高尔基体制备物使用两种形式的分析：（1）基底树突和一系列同心圆（其共同中心位于核周中心上方）之间的交叉点数量，以及（2）每个神经元按顺序排列的树突分支数量。数据表明，在老年动物中，在核周约150μ半径内，树突树的密度显着降低，但树突结构域的范围没有明显变化。对树突分支的分析表明，不仅树突树的外围分支发生了恶化，而且整个树突都已经丢失。通过从听觉皮层的 1-μ 塑料连续切片重建 V 层神经元周核及其近端树突，证实了这种初级分支的丢失。随着年龄的增长，树突会逐渐丧失，老年动物的核周体有变小但不扭曲的趋势。
The basal dendritic trees of layer V pyramidal cells in the rat auditory cortex were examined quantitatively in a group of 3‐month‐old and a group of 34‐ and 36‐month‐old rats. Two forms of analysis were used on the Golgi preparations: (1) the number of intersections between the basal dendrites and a series of concentric circles whose common center lies over the perikaryon center, and (2) the number of dendritic branches, by order, per neuron. The data indicate that in the old animals the density of the dendritic tree has decreased significantly within a radius of about 150 μ of the perikaryon, yet the extent of the dendritic domain has not changed appreciably. Analysis of the dendritic branching suggests that there has been a deterioration not only in the peripheral branches of the dendritic tree, but also that entire dendrites have been lost. This loss of primary branches was confirmed through the reconstruction of layer V neuronal perikarya and their proximal dendrites from 1‐μ plastic serial sections of auditory cortex. Concomitant with the loss of dendrites which accompanies advancing age is a tendency for the perikaryon to be smaller, but not distorted, in the old animals.