RESPONSE TO INJURY OF SKIN INVOLVED AND UNINVOLVED WITH PSORIASIS, AND ITS RELATION TO DISEASE-ACTIVITY - KOEBNER AND REVERSE KOEBNER REACTIONS
RESPONSE TO INJURY OF SKIN INVOLVED AND UNINVOLVED WITH PSORIASIS, AND ITS RELATION TO DISEASE-ACTIVITY - KOEBNER AND REVERSE KOEBNER REACTIONS
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DOI：
10.1111/j.1365-2133.1982.tb00924.x
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发表时间：
1982-01-01
影响因子：
10.3
通讯作者：
KRUEGER, GG
中科院分区：
文献类型：
--
作者：
EYRE, RW;KRUEGER, GG
The response to a standard skin injury in the involved and uninvolved skin of 24 subjects wth psoriasis was studied to determine whether a relationship exists between disease activity and the Koebner reaction. Of the patients, 25% had a positive Koebner reaction and 67% had a positive reverse Koebner reaction (psoriasis clearing following skin injury). If psoriasis occurred in 1 area of injury, all injured areas developed psoriasis, an all-or-none phenomenon. If psoriasis cleared from the traumatized area, no psoriasis occurred in the uninvolved sites. The reverse Koebner reaction and the Koebner reaction are mutually exclusive. Disease activity did not predict a positive Koebner reaction, but a positive Koebner reaction did predict subsequent disease activity. Humoral factors probably govern the development or clearing of psoriasis after a standard injury.
