Smoking cessation in smokers who smoke menthol and non-menthol cigarettes
Smoking cessation in smokers who smoke menthol and non-menthol cigarettes
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DOI：
10.1111/add.12661
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发表时间：
2014-12-01
期刊：
影响因子：
6
通讯作者：
Baker, Timothy B.
中科院分区：
文献类型：
--
作者：
Smith, Stevens S.;Fiore, Michael C.;Baker, Timothy B.
目的在一项大型比较有效性试验(CET)中评估薄荷醇香烟的使用与戒烟成功率的关系。在一项随机、双盲、安慰剂对照的临床试验中，设计参与者被随机分配到六种药物治疗条件之一。所有参与者都接受了六次单独的咨询会议。设置美国威斯康星州两个社区的社区吸烟者。参与者总共1504名成年吸烟者，他们在过去6个月里每天至少抽10支烟，并报告有戒烟动机。分析样本包括1439名参与者：814名白人非薄荷醇吸烟者，439名白人薄荷醇吸烟者和186名非裔美国人(AA)薄荷醇吸烟者。纳入分析的AA非薄荷醇吸烟者太少(n=16)。干预尼古丁含片、尼古丁贴片、安非他酮缓释片、尼古丁贴片+尼古丁含片、安非他酮+尼古丁含片和安慰剂。测量生化证实的7天点流行戒烟评估在戒烟后4、8和26周。发现在控制戒烟治疗的纵向戒烟分析(广义估计方程)中，薄荷醇吸烟与戒烟成功的可能性比不薄荷醇吸烟相关[基于模型的戒烟估计分别=31 38%；优势比(OR)=0.71，95%可信区间(CI)=0.59，0.86]。此外，在薄荷醇吸烟者中，AA女性比白人女性戒烟失败的风险特别高(估计戒烟率分别为17比35%；OR=2.63，95%CI=1.75，3.96；AA男性和白人男性的估计戒烟率均为30%，OR=1.06，95%CI=0.60，1.66)。结论在美国，与不吸烟薄荷醇香烟相比，吸烟薄荷醇香烟似乎与戒烟成功率降低有关，尤其是在非裔美国女性中。
AimsTo assess the relations of menthol cigarette use with measures of cessation success in a large comparative effectiveness trial (CET).DesignParticipants were randomized to one of six medication treatment conditions in a randomized double-blind, placebo-controlled clinical trial. All participants received six individual counseling sessions.SettingCommunity-based smokers in two communities in Wisconsin, USA.ParticipantsA total of 1504 adult smokers who smoked at least 10 cigarettes per day during the past 6 months and reported being motivated to quit smoking. The analysis sample comprised 1439 participants: 814 white non-menthol smokers, 439 white menthol smokers and 186 African American (AA) menthol smokers. There were too few AA non-menthol smokers (n=16) to be included in the analyses.InterventionsNicotine lozenge, nicotine patch, bupropion sustained release, nicotine patch+nicotine lozenge, bupropion+nicotine lozenge and placebo.MeasurementsBiochemically confirmed 7-day point-prevalence abstinence assessed at 4, 8 and 26 weeks post-quit.FindingsIn longitudinal abstinence analyses (generalized estimating equations) controlling for cessation treatment, menthol smoking was associated with reduced likelihood of smoking cessation success relative to non-menthol smoking [model-based estimates of abstinence=31 versus 38%, respectively; odds ratio (OR)=0.71, 95% confidence interval (CI)=0.59, 0.86]. In addition, among menthol smokers, AA women were at especially high risk of cessation failure relative to white women (estimated abstinence=17 versus 35%, respectively; OR=2.63, 95% CI=1.75, 3.96; estimated abstinence rates for AA males and white males were both 30%, OR=1.06, 95% CI=0.60, 1.66).ConclusionIn the United States, smoking menthol cigarettes appears to be associated with reduced cessation success compared with non-menthol smoking, especially in African American females.