ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity
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DOI：
10.1089/dna.2017.3791
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发表时间：
2017-07-01
影响因子：
3.1
通讯作者：
Dorf, Martin E.
中科院分区：
文献类型：
--
作者：
Li, Shitao;Fu, Bishi;Dorf, Martin E.
锌金属蛋白酶ZMPSTE24是一种结构性且普遍表达的宿主限制因子，可限制甲型流感病毒、水泡性口炎病毒、寨卡病毒、埃博拉病毒、辛德比斯病毒、牛痘病毒和牛痘病毒的感染，但不能限制小鼠白血病或腺病毒的感染。抗病毒功能不依赖于ZMPSTE24的酶活性。蛋白质相互作用和遗传互补研究表明，ZMPSTE24是与干扰素诱导的跨膜蛋白相关的常见抗病毒途径的一个组成部分。对ZMPSTE24基因缺陷小鼠的体内研究证明了ZMPSTE24对于抗病毒防御的重要性。
The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and genetic complementation studies indicate that ZMPSTE24 is a component of a common antiviral pathway that is associated with interferon-induced transmembrane proteins. In vivo studies with zmpste24-deficient mice demonstrate the importance of ZMPSTE24 for antiviral defense.