Noncoordinate expression of odorant receptor genes tightly linked in the zebrafish genome
Noncoordinate expression of odorant receptor genes tightly linked in the zebrafish genome
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DOI：
10.1016/s0896-6273(00)80945-9
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发表时间：
1997-08-01
期刊：
影响因子：
16.2
通讯作者：
Ngai, J
中科院分区：
文献类型：
--
作者：
Barth, AL;Dugas, JC;Ngai, J
我们已经表征了在类似于100 kb的斑马鱼基因组内聚集的气味受体基因的组织和表达。对该基因组区域的物理分析表明，受体基因在串联阵列中紧密相连。这些基因的表达模式进行了评估，以及在成人嗅上皮发育过程中。高度相关的基因在不同的嗅觉神经元中单独表达，这表明脊椎动物嗅觉系统的辨别能力已经通过将最相似的受体分离到不同的细胞通路中而最大化。此外，来自该簇的基因在不同的发育时期被激活。总之，这些结果表明，基因组连接的气味受体基因不协调调节。
We have characterized the organization and expression of odorant receptor genes clustered within similar to 100 kb of the zebrafish genome. Physical analysis of this genomic region reveals that the receptor genes are tightly linked in tandem arrays. The expression patterns of these genes were evaluated during development as well as in the adult olfactory epithelium. Highly related genes from this array are expressed individually in different olfactory neurons, suggesting that the discriminatory capacity of the vertebrate olfactory system has been maximized by segregating the most similar receptors into distinct cellular pathways. Furthermore, genes from this cluster are activated at different times of development. Together, these results indicate that genomically linked odorant receptor genes are not coordinately regulated.