A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants
A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants
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DOI：
10.1017/s0012162200000311
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发表时间：
2000-03-01
影响因子：
3.8
通讯作者：
Birch, DG
中科院分区：
文献类型：
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作者：
Birch, EE;Garfield, S;Birch, DG
一项随机临床试验评估了婴儿期膳食二十二碳六烯酸 (DHA) 供应对健康足月婴儿后期认知发育的影响，试验对象为添加 0.35% DHA 或添加 0.36% DHA 和 0.72% 花生四烯酸 (AA) 的婴儿配方奶，或不含 DHA 或 AA 的对照配方奶，纳入了 56 名 18 个月大的儿童（26 名男性，30 名女性）。该试验使用德克萨斯州达拉斯市西南视网膜基金会的婴儿发育贝利量表第二版 (BSID-II) (Bayley 1993) 在出生后 5 天内进行，并按照指定饮食喂养至 17 周龄。这些儿童在 4 个月和 12 个月大时还接受了血液脂肪酸成分、扫描视觉诱发电位 (VEP) 敏锐度和强制选择优先注视 (FPL) 敏锐度的评估（Birch 等，1998）。婴儿配方奶粉中添加 DHA+AA 与 BSID-II 的智力发展指数 (MDI) 平均增加 7 分相关，BSID-II 的认知和运动分量表均增加了 7 分。与对照组相比，MDI 显示 DHA 和 DHA+AA 补充组具有显着的发育年龄优势。虽然语言分量表也发现了类似的趋势，但并未达到统计显着性。 BSID-II 的精神运动发展指数和行为评定量表均未显示饮食组之间存在显着差异，这与 DHA 的特定优势一致。对智力发育的补充。 4 个月龄血浆和 RBC-DHA（但 12 个月龄）与 18 个月龄 MDI 之间不存在显着相关性，这表明早期饮食供应 DHA 是改善 MDI 表现的主要饮食决定因素。
The effects of dietary docosahexaenoic acid (DHA) supply during infancy on later cognitive development of healthy term infants were evaluated in a randomized clinical trial of infant formula milk supplemented with 0.35% DHA or with 0.36% DHA and 0.72% arachidonic acid (AA), or control formula which provided no DHA or AA, Fifty-six 18-month-old children (26 male, 30 female) who were enrolled in the trial within the first 5 days of life and fed the assigned diet to 17 weeks of age were tested using the Bayley Scales of Infant Development, 2nd edition (BSID-II) (Bayley 1993) at the Retina Foundation of the Southwest, Dallas, TX. These children had also been assessed at 4 months and 12 months of age for blood fatty-acid composition, sweep visual evoked potential (VEP) acuity, and forced-choice preferential looking (FPL) acuity (Birch et al, 1998), Supplementation of infant formula with DHA+AA was associated with a mean increase of 7 points on the Mental Development Index (MDI) of the BSID-II, Both the cognitive and motor subscales of the MDI showed a significant developmental age advantage for DHA- and DHA+AA-supplemented groups over the control group. While a similar trend was found for the language subscale, it did not reach statistical significance. Neither the Psychomotor Development Index nor the Behavior Rating Scale of the BSID-II showed significant differences among diet groups, consistent with a specific advantage of DHA. supplementation on mental development. Significant correlations between plasma and RBC-DHA at 4 months of age but not at 12 months of age and MDI at 18 months of age suggest that early dietary supply of DHA was a major dietary determinant of improved performance on the MDI.