Photooxidase-Mimicking Nanovesicles with Superior Photocatalytic Activity and Stability Based on Amphiphilic Amino Acid and Phthalocyanine Co-Assembly
Photooxidase-Mimicking Nanovesicles with Superior Photocatalytic Activity and Stability Based on Amphiphilic Amino Acid and Phthalocyanine Co-Assembly
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DOI：
10.1002/anie.201811478
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发表时间：
2019-02-11
影响因子：
16.6
通讯作者：
Yan, Xuehai
中科院分区：
文献类型：
--
作者：
Han, Jingjing;Liu, Kai;Yan, Xuehai
酶模拟物在催化领域具有广泛的应用，可以帮助阐明天然酶的催化机制。然而，催化位点的设计、主体分子的选择以及它们与活性三维结构的整合带来了挑战。在此，我们描述了通过协同分子自组装开发光氧化酶模拟物。 9-芴基甲氧基羰基-L-组氨酸与酞菁有效共组装成粒径和膜厚度可调的纳米囊泡。所获得的纳米囊泡可用作活性氧介导的光敏氧化的催化剂，具有更高的效率和稳定性。这项工作强调了将简单构件共同组装成超分子光催化剂，这可能有助于深入了解光催化膜系统的可能进化路径，并可能允许轻松转移到光敏纳米反应器或人工细胞器中。
Enzyme mimics have broad applications in catalysis and can assist elucidation of the catalytic mechanism of natural enzymes. However, challenges arise from the design of catalytic sites, the selection of host molecules, and their integration into active three-dimensional structures. Herein, we describe the development of a photooxidase mimic by synergetic molecular self-assembly. 9-Fluorenylmethyloxycarbonyl-l-histidine undergoes efficient co-assembly with phthalocyanine into nanovesicles with tunable particle size and membrane thickness. The obtained nanovesicles can be used as catalysts for reactive-oxygen-mediated photosensitive oxidation with improved efficiency and stability. This work highlights the co-assembly of simple building blocks into a supramolecular photocatalyst, which might give insight into possible evolutionary paths of photocatalytic membrane systems, and might allow facile transfer into photosensitive nanoreactors or artificial organelles.